关键词: 脐血, 砷, 胎儿, 体格生长

Abstract: 【Objective】 To investigate the level of arsenic (As) exposure during the fetal period in Shanghai,and analyze the relationship between neonatal physical growth indicators and arsenic levels in umbilical cord blood. 【Methods】 Umbilical cord blood samples were collected from pregnant women in Shanghai during October 2008 and October 2009.The arsenic levers in umbilical cord blood were measured by inductively coupled plasma emission mass spectroscopy (ICP-MS).The birth weight (BW),birth length (BL) and head circumference (HC) of the newborns delivered to the subjects were measured and the association of arsenic exposure with physical growth indicators was assessed by linear correlation analyses. 【Results】 291 umbilical cord blood were collected and measured,the maximum of total As was 24.87 μg/L,and the minimum was 1.81 μg/L,the geometric mean of total As in umbilical cord blood was (5.48±3.49) μg/L,Median was 5.42μg/L.In this range of exposure,there were no dose-effect associations between BW,BL and As levels,both in boys and girls.However,significant positive dose effects were found with As levels and HC in boys (r=0.25,P=0.004). 【Conclusion】 The level of arsenic during fetal period is low in Shanghai,and it found that there is no effect on BW and BL in this range of arsenic exposure.

Key words: umbilical cord blood, arsenic, fetus, physical growth