journal1 ›› 2017, Vol. 25 ›› Issue (2): 112-116.DOI: 10.11852/zgetbjzz2017-25-02-02

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A case-control study on the MMP-8C-799T and susceptibility to spontaneous preterm birth and premature rupture of membranes

YANG Xiao1,PENG Wei1,ZHU Li-na1,ZHANG Xiao-ai2,WANG Yan1   

  1. 1 Developmental Biology Laboratory,Bayi Children's Hospital Affiliated to PLA Army Beijing General Hospital,Beijing 100700,China;
    2 State Key Laboratory of Pathogen and Biosecurity Affiliated to the Institute Microbiology and Epidemiology of the Academy of Military Medical Sciences,Beijing,100071,China
  • Received:2016-08-12 Online:2017-02-10 Published:2017-02-10
  • Contact: WANG Yan,E-mail:001wangyan@sina.com

金属蛋白酶8基因 C-799T多态性位点与自发性早产遗传易感性的病例对照研究

杨晓1,彭薇1,朱丽娜1,张小爱2,王艳1   

  1. 1 中国人民解放军陆军总医院附属八一儿童医院发育生物学实验室,北京 100700;
    2 军事医学科学院微生物和流行病学研究所病原微生物生物安全重点实验室,北京 100071
  • 通讯作者: 王艳,E-mail001wangyan@sina.com
  • 作者简介:杨晓(1981-),女,湖北人,主管技师,博士学位,主要进行儿童遗传性疾病的细胞分子遗传学研究。
  • 基金资助:
    国家自然科学基金(81300527)

Abstract: Objective To investigate the association between the genetic polymorphisms of MMP-8C-799T and susceptibility to spontaneous preterm birth (SPTB). Methods This case-control study enrolled 753 SPTB singleton neonates and 681 term neonates.Polymorphism was genotyped using Sequenom MassARRAY SNP. Result Compared with the CC genotypes,MMP-8-799T-positive genotypes (CT+TT genotypes) were significantly associated with a decreased susceptibility to SPTB and moderate SPTB.The -799T-positive genotypes (CT+TT genotype) were also significantly associated with decreased SPTB susceptibility in preterm neonates with PROM.Comparing with the CC + CT genotypes,-799TT genotype was marginally associated with a decreased SPTB susceptibility in preterm neonates without PROM. Conclusion MMP-8C-799T contributes to the SPTB susceptibility.

Key words: matrix metalloproteinases-8, spontaneous preterm birth, premature rupture of membranes, single nucleotide polymorphisms

摘要: 目的 探讨金属蛋白酶8(MMP-8)基因C-799T多态性位点与自发性早产遗传易感性的关联性。方法 病例组样本包括753例自发性早产(SPTB)新生儿,对照组包括681例足月新生儿。采用最新的Sequenom MassARRAY SNP检测技术对MMP-8基因C-799T多态性位点进行SNP分型。结果 与携带MMP-8基因C-799T 多态性位点CC基因型的个体相比,携带至少一个-799 T等位型(CT+TT基因型)的个体发生SPTB、合并PROM的SPTB(PPROM)以及轻度早产的风险显著降低。与携带至少一个C等位型(CC+CT基因型)的个体相比,TT基因型与不合并PROM的SPTB的患病风险的降低有临界的相关性。结论 MMP-8基因C-799T多态性位点可以影响SPTB的遗传易感性。

关键词: 金属蛋白酶-8, 自发性早产, 胎膜早破, 单核苷酸多态性 中图分类号R179 文献标识码A 文章编号1008-6579(2017)02-0112-05 doi10.11852/zgetbjzz2017-25-02-02

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