Abstract: Objective To establish reference intervals of serum iron,magnesium,zinc and copper in healthy infants aged 0 to 12 months in Changchun,in order to provide reference for clinical diagnosis and treatment. Methods According to industry standards of health WS/T 402-2012 and after screening by clinical and laboratory standards,8 905 infants aged 0 to 12 months who took physical examination in the First Hospital of Jilin University were enrolled from January 2014 to December 2017.Serum iron,magnesium,zinc and copper were tested by Hitachi 7600-210 automatic biochemical analyzer and were classified according to age and gender.Data were analyzed by SPSS 21.0 and then the reference intervals for age and gender were obtained. Results Serum iron levels gradually decreased with months and serum magnesium concentration gradually increased with months.After gradually increasing with months,serum zinc level in boys and girls trended to peak at 7 to 8 months old and 5 to 6 months old,respectively,and then gradually declined.Serum copper level increased with months,peaking at 11 to 12 months old.There were age differences on the reference intervals of the four trace elements,and serum copper began to show gender differences from 4 to 12 months old. Conclusion It is of great significance to establish age-and sex-related reference intervals for serum trace elements in infants for the correct assessment of infant development.

Key words: iron, magnesium, zinc, copper, referenceintervals, infants

摘要： 目的 建立长春地区0~12个月健康婴儿血清铁、镁、锌、铜参考区间,为临床诊疗提供依据。方法 根据卫生行业标准WS/T 402-2012,经临床标准和实验室标准筛选后,选取2014年1月-2017年12月在吉林大学第一医院儿童体检中心体检的8 905名0~12月健康婴儿,使用日立7600-210全自动生化分析仪检测血清铁、镁、锌、铜,进行年龄、性别分组。使用SPSS 21.0统计软件进行分析,获得不同年龄段和性别分组的参考区间。结果 血清铁浓度随着月龄增加呈逐渐下降趋势,而血清镁浓度随月龄增加而逐渐升高。血清锌水平随月龄增加而逐渐升高,男婴、女婴分别在7~8个月、5~6个月达到高峰,此后逐渐下降。血清铜含量随着月龄增加,在11~12个月达高峰。四种微量元素参考区间均有年龄差异(P<0.05),血清铜在4~12个月开始有性别差异(P<0.05)。结论 建立各地区婴儿年龄与性别相关的血清元素参考区间对正确评估婴儿发育具有重要意义。

关键词: 铁, 镁, 锌, 铜, 参考区间, 婴儿