Abstract: Objective To master the distribution of thyroid volume and goiter of the children aged 8 to 10 years in Shaanxi province, in order to establish local reference range. Methods A total of 39 counties (cities, districts) were randomly selected from Shaanxi province in 2019.From each county, one primary school was randomly sampled from each selected town, which located in five different geographic directions: east, west, south, north and middle in each county.Finally, 42 non-boarding students aged 8-10 years were selected from each primary school, and their thyroids were examined by B-ultrasonography and random urine samples were tested. Results Totally 7 762 children aged 8 to 10 years were investigated.The median urinary iodine concentrations (MUIs) of children were 209.90 μg/L, and the iodine nutrition level of children was more than adequate condition.MUIs in each investigated area were above 100 μg/L, and the iodine nutritional status had been considered sufficient.The data of the thyroid volume (TVol) was abnormal distribution and the median of TVol was 2.68 ml.Children′s TVol was progressively increasing with age.But there was no significant difference on TVol between the male and the female children(Z＝0.62, P>0.05).The lowest median of TVol appeared in Hanzhong city (1.90 ml), while the highest was in Ankang city (4.30 ml).The upper limit of normal thyroid volume of children at the age of 8, 9 and 10 years old was 4.4, 4.8 ml and 5.7 ml, respectively. Conclusion There is difference between the results of this study and the Chinese national standard, which can provide reference for monitoring iodine deficiency disorder (IDD) in Shaanxi province and establishing local normative values of TVol for children aged 8 to 10 years.

Key words: thyroid volume, iodine nutrition, children, iodized salt

摘要： 目的 了解陕西省8~10岁儿童甲状腺容积分布及肿大情况,建立本省8~10岁儿童甲状腺容积的参考值范围。方法 2019年在全省10个市随机抽取39个县,在每个县(区、市)按东西南北中随机抽取1个乡(镇)/街道,每个乡(镇)/街道各抽取1所小学,每所小学抽取8~10岁非寄宿学生42人,B超法测量甲状腺容积并采集一次性随机尿样检测尿碘含量。结果 共调查7 762名陕西省8～10岁儿童,尿碘中位数为209.90 μg/L,各年龄儿童碘营养水平处于足量状态。各调查县(区)尿碘中位数均>100 μg/L,碘营养水平为足量水平。陕西省儿童甲状腺容积数据不服从正态分布,呈右偏态分布,中位数为2.68 ml。甲状腺容积随年龄增长而递增,不同性别儿童的甲状腺容积比较差异均无统计学意义(Z＝0.62,P＞0.05)。10个市中汉中市儿童甲状腺容积水平最低(1.90 ml),安康市最高(4.30 ml)。陕西省8~10岁儿童甲状腺容积的参考值标准按年龄分组分别为:4.4、4.8和5.7 ml。结论 本研究结果与国家标准有一定差异,可为今后陕西省碘缺乏病监测及建立本地区儿童甲状腺容积参考值标准提供依据。

关键词: 甲状腺容积, 碘营养, 儿童, 食用碘盐