Functional near-infrared spectroscopy study in children with developmental delay

doi:10.11852/zgetbjzz2021-0208

Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (7): 772-774.DOI: 10.11852/zgetbjzz2021-0208

• Clinical Research • Previous Articles Next Articles

Functional near-infrared spectroscopy study in children with developmental delay

QUAN Yan^*, LUO Li, CHEN Ling, WEI Wen-xi, CHEN Ying-rui, LIU Ping, ZHANG Yu, LI Hong-hui, ZENG Ting

^*Department of Child Health Care, Liuzhou Maternity and Child Healthcare Hospital,Key Laboratory of Developmental Disorders in Children of Liuzhou, Guangxi Health Commission Key Laboratory of Birth Cohort Study in Pregnant Women of Advanced Age, Liuzhou, Guangxi 545001, China

Received:2021-02-04 Revised:2021-04-28 Online:2021-07-10 Published:2021-07-28
Contact: ZENG Ting, E-mail:zengting2008@126.com

发育迟缓儿童的功能性近红外光谱研究

全琰¹, 罗荔¹, 陈玲¹, 韦雯曦¹, 陈莹睿², 刘萍¹, 张玉¹, 李红辉¹, 曾婷¹

1.广西柳州市妇幼保健院儿童保健科,柳州市儿童发育障碍疾病研究重点实验室,广西卫健委高龄孕产妇出生队列研究重点实验室,广西柳州 545001;
2.北京师范大学

通讯作者: 曾婷,E-mail:zengting2008@126.com
作者简介:全琰(1983-),女,广西人,主治医师,学士学位,主要研究方向为儿童脑认知功能。
基金资助:
广西重点研发计划(桂科AB18126056);柳州重点研发计划(2018BJ10301);柳州市科技计划项目(2018DB20501)

Abstract

Abstract: Objective To study the characteristics of children with developmental delay (DD) by using functional near infrared spectroscopy (fNIRS), so as to provide reference for the individual diagnosis and treatment of DD. Methods A total of 13 children with DD(DD group) and 19 normal children (NC group) were selected in this study, whose brain function was tested by 8-channel fNIRS. Multiscale entropy (MSE) of each channel and the mean MSE of the frontal region between DD group and NC group were compared by t test. Results The mean MSE of DD group (1.570±0.491) was significantly lower than that of NC group (2.075±0.791) (t=2.228, P＝0.034). The MSE values in channel 3 and 8 were significantly different between DD group and NC group(t=2.513, 2.868, P＜0.01). Conclusions Compared with the normal control group, the complexity of frontal lobe spontaneous brain signals in children with DD is significantly lower, indicating that children with DD have bilateral prefrontal brain function impairment.

Key words: functional near-infrared spectroscopy, developmental delay, children

摘要： 目的探讨发育迟缓儿童的功能性近红外光谱(fNIRS)特点,为发育迟缓儿童的脑功能分析提供参考依据。方法 2019年11日-2020年6月应用8通道功能性近红外光谱成像技术(fNIRS)检测13名发育迟缓儿童(发育迟缓组)和年龄、性别相匹配的19例健康儿童(正常组)的脑功能情况,采用独立样本t检验比较两组儿童各通道多尺度熵(MSE)及前额区MSE均值的差异。结果发育迟缓组和正常组儿童前额区MSE均值分别为1.570±0.491、2.075±0.791,两组间差异具有统计学意义(t=2.228, P＝0.034)。两组儿童的MSE均值在3通道和8通道差异统计学意义(t＝2.513、2.868,P<0.01)。结论发育迟缓儿童前额区自发脑信号的复杂性较正常健康儿童明显偏低,发育迟缓儿童存在前额叶双侧脑功能受损。

关键词: 功能性近红外光谱, 发育迟缓, 儿童

CLC Number:

R741

QUAN Yan, LUO Li, CHEN Ling, WEI Wen-xi, CHEN Ying-rui, LIU Ping, ZHANG Yu, LI Hong-hui, ZENG Ting. Functional near-infrared spectroscopy study in children with developmental delay[J]. Chinese Journal of Child Health Care, 2021, 29(7): 772-774.

全琰, 罗荔, 陈玲, 韦雯曦, 陈莹睿, 刘萍, 张玉, 李红辉, 曾婷. 发育迟缓儿童的功能性近红外光谱研究[J]. 中国儿童保健杂志, 2021, 29(7): 772-774.

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Functional near-infrared spectroscopy study in children with developmental delay

发育迟缓儿童的功能性近红外光谱研究

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