Abstract: Objective To study the difference of blood amino acids and acyl carnitine between full-term small for gestational age newborns and their matched full-term suitable for gestational age newborns, so as to provide reference for the supplementation of amino acids in full-term small for gestational age newborns. Methods From April 2019 to July 2020, a total of 57 cases of full-term small for gestational age newborns in Hunan Provincial Maternal and Child Health Hospital were selected into study group, and meanwhile 57 cases of matched full-term suitable for gestational age newborns born in this hospital were selected as the control group.The levels of blood amino acids and acyl carnitine between the two groups were measured respectively, and their differences were analyzed. Results There were no significant differences in butyryl carnitine, 3-hydroxy isoamyl carnitine, isoamyl carnitine, sunoyl carnitine, leucine and methionine between study group and control group (t=1.707, 1.122, 1.122, 1.638, 1.855, 1.638, P>0.05), but significant differences existed in propionyl carnitine, free carnitine, myristoyl carnitine, octanoyl carnitine, tyramine and valine between the two groups (t=5.524, 3.392, 4.530, 4.716, 4.530, 3.547, P<0.05). Conclusions There are significant differences in blood amino acids and acyl carnitine between full-term small for gestational age newborns and full-term suitable for gestational age newborns, so full-term small for gestational age newborns are given critical attention from clinicians.It is supposed to supplement amino acids for full-term small for gestational age newborns as soon as possible, and to encourage early mobilization of medium and long chain fatty acids to stabilize energy metabolism.

Key words: acyl carnitine, full-term small for gestational age newborns, blood amino acids, full-term suitable for gestational age newborns

摘要： 目的 研究足月小于胎龄新生儿和足月适于胎龄新生儿血氨基酸和酰基肉碱的差异,为足月小于胎龄新生儿补充氨基酸提供参考依据。方法 选择河南省妇幼保健院2019年4月-2020年7月纳入的57例足月小于胎龄新生儿作为研究组,另选择2019年4月-2020年7月在本院出生的57例足月适于胎龄儿新生儿作为对照组,分别测定两组的血氨基酸和酰基肉碱的水平,分析其差异。结果 研究组和对照组在丁酰基肉碱、3-羟基异戊酰基肉碱、异戊烯酰基肉碱、葵酰基肉碱、亮氨酸、甲硫氨酸上相比差异无统计学意义(t=1.707、1.122、1.122、1.638、1.855、1.638,P>0.05),但研究组在丙酰基肉碱、游离肉碱、肉豆蔻二烯酰基肉碱、辛酰基肉碱、酪氨酸、缬氨酸上与对照组差异显著(t=5.524、3.392、4.530、4.716、4.530、3.547,P＜0.05)。结论 与足月适于胎龄新生儿相比,足月小于胎龄新生儿在血氨基酸和酰基肉碱上存在显著差异,受到临床重点关注,尽早为足月小于胎龄新生儿补充氨基酸,并鼓励早期通过动员中长链脂肪酸方式稳定能量代谢。

关键词: 酰基肉碱, 足月小于胎龄新生儿, 血氨基酸, 足月适于胎龄新生儿