Abstract: 【Objective】 To analyze the variation trends of serum IGF-1 levels in healthy infants and the relationship of IGF-1 with the growth velocity and feeding pattern of infants. 【Methods】 IGF-I concentrations were measured in 544 healthy infants. They were all full term and appropriate for gestational age infants, and were born between 2006 and 2008 in the Third Hospital of Peking University, with their height and weight measured and their feeding patterns recorded every 1 to 2 months in this hospital. At the time of analyzing the relationship of IGF-1 levels with the growth velocity and feeding, gender and number of months after birth were adjusted. 【Results】 Serum IGF-1 level witnessed a small peak in 2-3 months after birth, dropped rapidly thereafter, reached the lowest point in 7~8 months after birth, and slowly increased in the following months. Serum IGF-1 levels were significantly higher in females [112.65 ng/mL, 95%CI:91.82~133.89] than in males [74.38 ng/mL,95%CI:53.14~95.61,P＜0.05] during early infancy. Infants receiving breast milk had lower serum IGF-I levels[(66.94±45.85) ng/mL] than infants receiving formula [(72.56±36.55)ng/mL] or both [(79.89±51.79)ng/mL;P=0.019]. IGF-1 levels were positively associated with growth velocity(P<0.01). 【Conclusions】 This study provided the variation trend for IGF-1 levels during infancy. IGF-1 may play a key role in regulation of infant statural growth and was influenced by the feeding pattern.

Key words: insulin-like growth factor-1, growth and development, feeding, infant

摘要： 【目的】 分析正常婴儿血清胰岛素样生长因子-1(insulin-like growth factor-1, IGF-1)水平变化趋势及IGF-1与婴儿生长发育及喂养方式关系。 【方法】 检测了544名健康婴儿血清IGF-1,这些婴儿均为足月适于胎龄儿,于2006-2008年出生在北京大学第三医院,每1~2月在该院儿科进行一次身高、体重测量,记录喂养方式。分析IGF-1水平与生长速度及喂养关系时,对性别、月龄进行了修正。 【结果】 生后2~3月血清IGF-1水平存在一个小高峰,此后迅速下降,7~8个月为最低,随后缓慢上升,婴儿早期女婴血清IGF-1水平[112.65 ng/mL,95%CI:91.82~133.89]高于男婴[74.38 ng/mL,95%CI:53.14~95.61,P<0.05];母乳喂养婴儿血清IGF-1 水平[(66.94±45.85) ng/mL低于配方乳(72.56±36.55) ng/mL]和混合喂养婴儿[(79.89±51.79) ng/mL;P=0.019];IGF-1水平与身高生长速度呈显著正相关关系(P<0.01)。 【结论】 本研究提供了婴儿期血清IGF-1变化趋势,IGF-1在调控婴儿身高增长方面很可能起重要作用,喂养方式影响血清IGF-1水平。

关键词: 胰岛素样生长因子-1, 生长发育, 喂养, 婴儿