journal1 ›› 2011, Vol. 19 ›› Issue (4): 373-376.

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Reevaluate of vitamin D intoxication diagnosis of reported cases in recent years in China and the criteria diagnosis and treatment of vitamin D intoxication

HU Yan-qi, SHENG Xiao-yang   

  1. Department of Child and Adolescent Health Care, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, Shanghai 200092, China
  • Received:2010-09-27 Online:2011-04-06 Published:2011-04-06

我国文献报道维生素D中毒病例诊断依据分析

胡燕琪,盛晓阳   

  1. 上海交通大学医学院附属新华医院儿童与青少年保健科,上海市环境与儿童健康重点实验室,上海 200092
  • 通讯作者: 盛晓阳,E-mail:shengxiaoyangcn@yahoo.com.cn
  • 作者简介:胡燕琪(1985-),女,上海人,硕士在读,主要研究方向为婴幼儿营养与健康

Abstract: 【Objectives】 To reevaluate the diagnosis of vitamin D overdose and intoxication in reported cases in China, to improve the awareness of pediatricians on vitamin D overdose and intoxication, and to properly administrate vitamin D supplements. 【Methods】 All the cases of vitamin D overdose and intoxication reported from January 2004 till May 2010 in major domestic database had been searched by keywords "vitamin D", "overdose", "intoxication". The clinical manifestation, laboratory finding, treatment and prognosis of these cases had been reviewed. 【Results】 A total of 11 references had been searched. There were 475 cases of vitamin D overdose and intoxication had been reported in these references. Among them, 23 cases (4.8%) meet vitamin D intoxication diagnosis criteria; 17 cases (3.6%) were overdose of vitamin D; 234 cases (49.3%) could not be confirmed because incomplete information; 201 cases (42.3%) were misdiagnosis. 【Conclusions】 Almost half of cases are misdiagnosed vitamin D overdose and intoxication. Long-term prophylactic supplement vitamin D is very important to prevent and reduce vitamin D deficiency in children. However, precaution vitamin D abuse or misuse also should be emphasized.

Key words: vitamin D, intoxication, diagnosis, treatment

摘要: 【目的】 分析和评估我国近年文献报道的维生素D过量和中毒病例,以期为临床医生正确认识维生素D中毒和预防性补充提供参考。 【方法】 检索国内主要数据库,收集2004年1月—2010年5月全部维生素D中毒、过量的文献报道,并对报道病例进行分析和总结。 【结果】 共检索到11篇文献,报道475例维生素D过量或中毒病例。依据目前维生素D过量和中毒诊断标准评估,其中仅23例(4.8%)符合维生素D中毒诊断;17例(3.6%)明确维生素D过量;234例(49.3%)无法肯定诊断;201例(42.3%)缺乏必要诊断依据。 【结论】 近年来我国确实存在维生素D中毒病例,但部分报道病例诊断依据明显不足。临床医生应警惕维生素D的滥用或误用,同时提高对长期预防性补充维生素D的认识。

关键词: 维生素D, 中毒, 诊断, 治疗

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