Abstract: 【Objective】 To measure the levels of blood trace elements and serum bone alkaline phosphatase(BALP) in children with idiopathic short stature and investigate their influences on the children's height. 【Method】 The levels of Blood Ca, Zn, Fe Cu, Mg, Pb and serum BALP were measured and analyzed in both idiopathic short stature group and control group. 【Result】 Both blood Ca, Zn levels were significantly lower than those of control group, but blood Pb and serum BALP levels were apparently higher than those of control group. 【Conclusions】 Pb exposure can influence children's height and that may be one factor of ISS as well as the short of blood Ca and Zn. In addition, the level of serum BALP in children with idiopathic short stature can be used as a curative effect symbol.

Key words: idiopathic short stature, serum Pb, trace element, bone alkaline phosphatase

摘要： 【目的】 探讨特发性身材矮小( idiopathic short stature, ISS) 儿童全血铜、铁、钙、镁、锌、铅以及血清骨碱性磷酸酶(bone alkaline phosphatase, BALP)水平,了解其对身高的影响。 【方法】 测定ISS组儿童及正常对照组儿童全血铜、铁、钙、镁、锌、铅及血清BALP水平并比较分析。 【结果】 ISS组儿童血铅及血清BALP水平均高于相应年龄段健康对照组儿童,血钙、血锌均低于对照组儿童,差异有统计学意义(P＜0.05或＜0.01)。 【结论】 铅暴露对儿童的身高有不良影响,可能是引起儿童ISS的因素之一,而血钙和血锌缺乏也影响了儿童的身高,此外ISS儿童体内BALP水平升高,可用于其疗效监测。

关键词: 特发性身材矮小, 血铅, 微量元素, 骨碱性磷酸酶