journal1 ›› 2019, Vol. 27 ›› Issue (1): 42-45.DOI: 10.11852/zgetbjzz2018-1320

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Effect of different intensities of exercise training on learning and memory in adolescent rats and the underlying mechanism

LIU Li1, GOU Wei2, XIE Wen3, CHEN Li3, LEI Xiao-mei4   

  1. 1 The Emergency Center,the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,Shaanxi 710061,China;
    2 Functional Experiment Center,Basic Medical School of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China;
    3 Physiology and Pathophysiology Department,Basic Medical School of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China;
    4 The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004,China
  • Received:2018-09-20 Online:2019-01-10 Published:2019-01-10
  • Contact: CHEN Li,E-mail:chenli2000@xjtu.edu.cn;LEI Xiao-mei,E-mail:CJCHCL123@sina.com

不同强度运动训练对青春期大鼠学习记忆能力的影响及其机制研究

刘利1, 苟伟2, 谢雯3, 陈丽3, 雷晓梅4   

  1. 1 西安交通大学第一附属医院急救中心,陕西 西安 710061;
    2 西安交通大学基础医学院机能教学实验中心,陕西 西安 710061;
    3 西安交通大学基础医学院生理学与病理生理学系,陕西 西安 710061;
    4 西安交通大学第二附属医院,陕西 西安 710004
  • 通讯作者: 陈丽,E-mail:chenli2000@xjtu.edu.cn;雷晓梅,E-mail:CJCHCL123@sina.com
  • 作者简介:刘利(1976-),男,陕西人,硕士研究生,主要研究方向为急慢性病的预防与治疗。
  • 基金资助:
    陕西省自然科学基金项目(2016JM8011);西安市科技计划项目(2017118SF/YX012(6))

Abstract: Objective To observe the effect of different intensities of exercise training on learning and memory of adolescent rats,as well as the relationship between training and serum leptin levels. Methods Totally 30 rats aged 45-50 days were selected and randomly divided into three groups,including low intensity exercise,moderate intensity exercise and control group,with 10 rats in each group. Morris water maze was used to observe the learning and memory of rats. The serum leptin level was tested by enzyme-linked immunosorbent assay (ELISA). Results The average escape latency of four morris water maze tests in the moderate intensity exercise was (44.8±5.0) s,(49.3±5.2) s,(39.3±4.7) s and (37.7±2.8) s,respectively,which were all shorter than those of control group(P<0.01). The number of crossing platform and the level of serum leptin in the moderate intensity exercise training group were significantly higher than those in normal group (15.1±4.5) pg/ml vs. (12.8±3.7) pg/ml,5.2±1.8 vs. 2.6±0.4,P<0.05). Conclusion Moderate intensity exercise training can improve learning and memory ability of adolescent rats,which may be related to the increase of serum leptin content.

Key words: learning and memory, exercise training, leptin, adolescent rats

摘要: 目的 观察不同强度的运动训练对青春期大鼠学习记忆能力的影响以及和血清瘦素水平的关系,为研究青春期学习记忆能力的提高提供依据。方法 选择30只45~50日龄大鼠,随机分为低强度运动组、中等强度运动组和对照组,每组10只,连续一周低强度或中等强度跑台运动训练,Morris水迷宫观察大鼠学习记忆,酶联免疫法检测血清瘦素(Lep)水平。结果 中等强度运动训练组大鼠Morris水迷宫实验四个象限的平均逃避潜伏期分别为(44.8±5.0)s,(49.3±5.2)s,(39.3±4.7)s和(37.7±2.8) s,均短于正常组大鼠(P<0.01),中等强度运动训练组大鼠穿越站台次数为5.2±1.8,高于正常组大鼠(2.6±0.4),差异均具有统计学意义(P<0.01)。中等强度运动组大鼠的血清Lep水平[(15.1±4.5) pg/ml]高于正常组大鼠[(12.8±3.7) pg/ml](t=2.47,P<0.05)。结论 中等强度的运动训练能够提高青春期大鼠的学习记忆能力,这可能与血清Lep含量的增加有关。

关键词: 学习记忆, 运动训练, 瘦素, 青春期大鼠

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