Meta-analysis of the prevalence of non-alcoholic fatty liver disease in Chinese children

doi:10.11852/zgetbjzz2021-1338

Abstract

Abstract: Objective To systematically evaluate the prevalence of non-alcoholic fatty liver disease (NAFLD) in Chinese children and obese children, so as to provide basis for epidemiological studies and clinical prevention and treatment of NAFLD. Methods CNKI, VIP, WanFang Data, CBM, PubMed, Cochrane Library, Embase and Web of Science were searched to collect studies on the prevalence of NAFLD in Chinese children and obese children from 2000 to 2021 in home and abroad.Meta-analysis was performed using R language (version 4.0.5).Random effect model was used to merge data, funnel plot, Egger's test and Begg's test were used to evaluate the risk of bias. Results A total of 25 studies were included, including 8 studies on the prevalence of NAFLD in children, and 17 studies on the prevalence of NAFLD in obese children.The total sample size of the study was 35 300, and the sample size of obese children was 7 649.Meta-analysis showed that the prevalence of NAFLD in Chinese children was 6.3% (95%CI: 4.6% - 7.9%), and the prevalence of NAFLD in obese children was 40.4% (95%CI: 31.5% - 49.9%).Subgroup analysis showed that the prevalence of NAFLD was significantly different by gender, research areas and research time. Conclusions The prevalence of NAFLD among Chinese children and obesity children is relatively high.NAFLD in children is gradually becoming one of the major public health problems in China.

Key words: non-alcoholic fatty liver disease, children, obesity, prevalence, Meta-analysis, China

摘要： 目的系统评价中国儿童及超重肥胖儿童非酒精性脂肪性肝病(NAFLD)患病率,为儿童及超重肥胖儿童 NAFLD 的流行病学研究和临床防治提供数据基础。方法计算机检索中国知网、维普网、万方数据知识平台、中国生物医学文献数据库、PubMed、The Cochrane Library、EMbase、Web of Science,收集 2000-2021 年之间的关于中国儿童及超重肥胖儿童 NAFLD 患病率的中英文研究。采用R语言(version 4.0.5)对提取数据进行 Meta 分析,以随机效应模型合并数据,运用漏斗图、Egger's test、Begg's test评估偏倚风险。结果共纳入 25项研究,其中 8 项研究为儿童NAFLD患病率,17 项研究为超重肥胖儿童 NAFLD 患病率,研究样本量总计 35 300例,其中肥胖儿童样本量为 7 649 例。Meta 分析结果显示,中国儿童 NAFLD 患病率为6.3%(95%CI:4.6%~7.9%),超重肥胖儿童 NAFLD 患病率为40.4%(95%CI:31.5%~49.9%)。亚组分析结果显示,不同性别、研究地区、研究时间的儿童及超重肥胖儿童NAFLD患病率存在差异。结论我国儿童及超重肥胖儿童 NAFLD 患病率较高,儿童 NAFLD 正逐渐成为我国重大公共卫生问题之一。

关键词: 非酒精性脂肪性肝病, 儿童, 肥胖, 患病率, Meta分析, 中国

CLC Number:

R725.7

WANG Yu, YANG Zhi-ran, CHEN Run-hua. Meta-analysis of the prevalence of non-alcoholic fatty liver disease in Chinese children[J]. Chinese Journal of Child Health Care, 2022, 30(7): 764-769.

王雨, 杨志然, 陈润花. 中国儿童非酒精性脂肪性肝病患病率的Meta分析[J]. 中国儿童保健杂志, 2022, 30(7): 764-769.

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