Abstract

摘要： 铁缺乏是常见的单一营养素缺乏,近年来的研究发现铁缺乏加重注意缺陷多动障碍(attention dsficit hyperactivity disorder,ADHD)症状,铁剂补充可以改善ADHD症状,儿童早期铁缺乏影响ADHD对治疗药物的反应。本文对铁缺乏与ADHD的关系以及可能的机制进行总结,建议在ADHD的诊疗过程中常规评价患儿的铁营养状况,发现问题及早纠正。

关键词: 铁缺乏, 注意缺陷多动障碍, 中枢神经系统, 儿童

CLC Number:

R749.94

衣明纪 ,张小芳,胡晓燕. 铁缺乏与儿童注意缺陷多动障碍[J]. 中国儿童保健杂志, 2011, 19(12): 1113-1115.

[1] Murray-Kolb LE,Beard JL.Iron deficiency and child and maternal health[J].Am J Clin Nutr,2009,89(S):946-950.
[2] Konofal E,Lecendreux M,Arnulf I,et al.Iron deficiency in children with attention-deficit/hyperactivity disorder[J].Arch Pediatr Adolesc Med,2004,158(12):1113-1115.
[3] 李晓玲,王雪兰,黄丽丽.注意缺陷多动障碍与血清铁蛋白、血铅水平的相关性分析[J].中国实用神经疾病杂志,2010,13(19):9-11.
[4] 储晓彬,张瑜.儿童注意缺陷多动障碍与铁缺乏关系的研究[J].南通大学学报 :医学版,2006,26(6):492-494.
[5] Pelsser LMJ,Frankena K,Toorman J,et al. A randomised controlled trial into the effects of food on ADHD[J].Eur Child Adolesc Psychiatry,2008,18(1):12-19.
[6] Sinn N.Nutritional and dietary influences on attention deficit hyperactivity disorder[J].Nutr Rev,2008,66(10):558-568.
[7] Hergüner S,Kelesoglu FM,Tanidir C,et al.Ferritin and iron levels in children with autistic disorder[J].Eur J Pediatr,2011,170(10):1506-1511.
[8] Oner P,Oner O.Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder:effect of comorbidity[J].Child Psychiatry Hum Dev,2008,39(3):323-330.
[9] Konofal E,Cortese S,Marchand M,et al.Impact of restless legs and iron de?ciency on attention-deficit/hyperactivity disorder in children[J].Sleep Medicine,2007,8(7-8):711-715.
[10] Cortese S,Lecendreux M,Bernardina BD,et al.Attention-de?cit/hyperactivity disorder, Tourrete,s syndrome,and restless legs syndrome: the iron hypothesis[J].Med Hypotheses,2008,70(6):1128-1132.
[11] Cortese S,Konofal E,Bernardina BD,et al.Sleep disturbances and serum ferritin levels in children with attention-de?cit/hyperactivity disorder[J].Eur Child Adolesc Psychiatry,2009,18(7):393-399.
[12] Juneja M,Jain R,Singh V,et al.Iron Deficiency in Indian children with attention deficit hyperactivity disorder[J].Indian Pediatrics,2010,47(11):955-958.
[13] Konofal E, Lecendreux M, Deron J,et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children[J].Pediatr Neurol,2008,38(1):20-26.
[14] Konofal E,Cortese S,Lecendreux M,et al.Effectiveness of iron supplementation in a young child with attention-deficit/hyperactivity disorder[J].Pediatrics, 2005,116(5):e732-e734.
[15] Lozoff B,Jimenez E,Mollen E,et al.Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy[J].Pediatrics,2000,105(4):51-62.
[16] Calarge C,Farmer C,Disilvestro R,et al.Serum ferritin and amphetamine response in youth with attention-de?cit/hyperactivity disorder[J].J Child Adolesc Psychopharmacol,2010,20(6):495-502.
[17] Beard J.Iron deficiency alters brain development and functioning[J].J Nutr, 2003,133(S):1468-1472.
[18] Lukowski AF,Koss M,Burden MJ,et al.Iron deficiency in infancy and neurocognitive functioning at 19 years:evidence of long-term deficits in executive function and recognition memory[J].Nutri Neurosci,2010,13(2):54-70.
[19] Beard JL.Why iron deficiency is important in infant development[J].J Nutr,2008,138(12):2534-2536.
[20] 吴玲玲,赵正言.铁缺乏对中枢神经系统髓鞘化的影响[J].中国妇幼健康研究,2006,17(1):35-37.
[21] Burhans MS,Dailey C,Beard Z,et al.Iron deficiency:differential effects on monoamine transporters[J].Nutr Neurosci,2005,8(1):31-38.
[22] Biederman J.Attention-deficit/hyperactivity disorder:a selective overview[J].Biol Psychiatry.2005,57(11):1215-1220.
[23] Banaschewski T,Becker K,Scherag S,et al.Molecular genetics of attention-deficit/hyperactivity disorder: an overview[J].Eur Child Adolesc Psychiatry,2010,19(3): 237-257.
[24] Erickson KM,Jones BC,Hess EJ,et al.Iron deficiency decreases dopamine D1 and D2 receptors in rat brain[J].Pharmacol Biochem Behav,2001,69(3-4):409-418.
[25] Lozoff B.Perinatal iron deficiency and the developing brain[J].Pediatr Res,2000,48(2):137-139.

铁缺乏与儿童注意缺陷多动障碍

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