%0 Journal Article
%A JIN Hui
%A MA Lu-yi.
%T Effect of cyanidin-3-glucoside on low-grade inflammation and insulin sensitivity in diet-induced obese rats.
%D 2014
%R 10.11852/zgetbjzz2014-22-08-13
%J Chinese Journal of Child Health Care
%P 826-828
%V 22
%N 8
%X Objective To examine the effects of cyanidin-3-glucoside (C3G) on serum inflammatory cytokines and insulin sensitivity in diet-induced obese rats. Methods Thirty male Sprague-Dawley rats were randomly assigned to a control group (n=8) and a high fat diet group (n=22), and were fed with standard diet or high fat diet.Five weeks later, 17 high-fat diet-induced obese rats were assigned to a obese group (n=8) and a C3G group (n=9).Then, rats of obese group were treated with C3G at 100 mg/(kg·d) for 5 weeks.Body weight, visceral adiposity weight were measured, blood sample was collected for detecting levels of fasting glucose(FPG), fasting insulin(FINS), leptin, adiponectin, TNF-α, IL-6 and MCP-1, finally calculated visceral adiposity weight to body weight ratio(VBR) and insulin sensitivity index(IAI). Results Body weight, VBR, TNF-α, IL-6 and MCP-1 in the obese group were significantly higher than those of the control group (all P<0.05).The C3G group had significantly lower levels of body weight, VBR, TNF-α, IL-6 and MCP-1 than the obese group(all P<0.05), but the levels of the paremeters in the C3G group was significantly higher than that of the control group (P<0.05).Adiopnectin and insulin sensitivity index in the obese group was significantly lower than that of the control group (P<0.05), C3G treatment dramatically increased adiponectin levels and insulin sensitivity index compared with the obese group (P<0.05), although the levels of the two parameters did not reach to the levels of the control group. Conclusion Cyanidin-3-glucoside can increase insulin sensitivity through regulating serum inflammatory cytokines levels in obese rats.
%U https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2014-22-08-13