%0 Journal Article %A GUO Chun-yan %A HE Miao %A WAN Bin %A ZHAN Hai-rong %T Effect of infant growth on adolescent sexual development %D 2021 %R 10.11852/zgetbjzz2019-1833 %J Chinese Journal of Child Health Care %P 156-159 %V 29 %N 2 %X Objective To explore the effect of rapid growth in infancy on puberty sexual development, in order to provide reference for preventing early puberty in the future. Methods From January 2004 to January 2005, 198 infants who grew too fast were selected as the observation group and 175 normal infants were selected as the control group from Wenzhou Children's Hospital and Shiyan People's Hospital. According to the time point of menarche/ spermatorrhea, the observation group was divided into precocious puberty group and normal development group. Spearman correlation analysis was used to analyze the correlation between height Δvalue, weight Δvalue and puberty precocious puberty in the observation group. Results The height Δvalue and weight Δvalue of one-year-old infants in the observation group were significantly higher than those in the control group (t=2.085,2.146,P<0.05). The height, weight, body fat and bone age of children in the observation group were significantly higher than those in the control group, and the levels of testosterone(T), estradiol(E2), follicle stimulating hormone(FSH) and luteinizing hormone(LH) in the observation group were significantly higher than those in the control group (P<0.05). There were no sexual precocious children in the control group. There was no significant difference in gender among the precocious group,the normal group and the observation group (P>0.05). The height, weight, body fat and bone age of the precocious group were significantly higher than those of the normal group, and the levels of T, E2, FSH and LH in the precocious group were significantly higher than those in the normal group (P<0.05).There was a positive correlation between the height Δvalue and the weight Δvalue of one year old infants in the observation group and puberty precocious puberty (r=0.816, 0.872, P<0.001). Conclusions Rapid growth in infancy can lead to pre-puberty obesity and excessive body fat, and early puberty. It is of great significance to control the overgrowth during infancy for the prevention of early puberty in the future. %U https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2019-1833