%0 Journal Article %A AIERKEN Aibibai %A WANG Yi-lin %A XU Pei-ru %A SHANG Li %T Association of the single nucleotide polymorphism of NOS3 gene with obesity in children aged 6~13 years %D %R 10.11852/zgetbjzz2021-1179 %J Chinese Journal of Child Health Care %P 490-494 %V 30 %N 5 %X Objective To analyze the correlation of polymorphisms of NOS3 rs1799983, rs2566508 with obesity in children aged 6 to 13, in order to provide scientific basis for further exploration of obesity occurrence, development, prevention and treatment. Methods A cross-sectional survey was conducted at a primary school in Shawan City, Xinjiang Province in September 2019. According to the inclusion and exclusion criteria, 100 cases were screened with obesity and 100 children were in control group. There were 122 cases of Han nationality and 78 cases of Kazakh. Chip capture sequencing and high-throughput sequencing technology were used to detect NOS3 gene rs1799983, rs2566508 polymorphism. Then their correlations with obesity among Han and Kazakh children were analyzed. Results 1) NOS3 gene rs2566508 polymorphism may be associated with obesity in Han girls aged 6 to 13 years. There were significant differences in the frequencies of T and G alleles distribution between the control group and obesity group (χ2=11.247, P=0.001). The risk of obesity increased significantly in carriers of G allele (OR=3.889, 95%CI:1.707 - 8.860). There were also significant differences in the frequencies of TT, TG and GG genotypes distribution between the two groups (χ2=10.389, P=0.004). However, no association between rs2566508 polymorphism and obesity was found in Han boys as well as Kazakh boys and girls. 2) The allele and genotype distribution frequencies of NOS3 gene rs1799983 were not statistically significant in the group differences between Han and Kazakh children (P>0.05). Conclusion NOS3 gene rs2566508 polymorphism may be associated with obesity in Han girls aged 6 to 13, and the risk of obesity increases significantly in the carriers of G allele. %U https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2021-1179