%0 Journal Article %A DONG Ming-ming %A HU-Dan %A MA Xian-zhi %A XIAO Xu-wu %A CUI Yi-fan %T Correlation of serum chemerin, leptin and adiponectin levels with glucose and lipid metabolism preschool simple obese children %D %R 10.11852/zgetbjzz2021-1197 %J Chinese Journal of Child Health Care %P 548-552 %V 30 %N 5 %X Objective To study the correlation of serum chemerin, leptin and adiponectin levels with simple obesity and metabolism in preschool children aged 3 to 6 years, so as to provide basis for clinical monitoring and treatment efficacy evaluation of preschool simple obese children. Methods Children aged 3 to 6 years who underwent physical examination in Child Health Clinic of Dalian Maternal and Child Health Hospital from January 2019 to May 2020 were selected as study subjects. Forty one simple obese children were enrolled in the study group, and meanwhile another 43 children with the same age were selected as the control group. Their height and weight were measured, and calculate the height for weight was calculated. Serum levels of chemerin, leptin, adiponectin, fasting plasma glucose (FPG), fasting insulin (FINS), total triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) were tested, and insulin resistance index was calculated. Results The levels of FINS, HOMA-IR, LDL-c, serum chemerin and leptin in the simple obesity group were significantly higher than those in the control group (t=3.288, 2.927, 4.939, 3.078, 5.456, P<0.05),while the levels of HDL-c and adiponectin were significantly lower than those in the control group (t=-5.179, -3.145, P<0.05). But there were no significant differences in the levels of FPG, TG and TC between the two groups (t=0.391, 0.768,-0.266, P>0.05). Serum chemerin was positively correlated with height for weight and the levels of FINS, HOMA-IR, TG, LDL-c and leptin (r=0.339, 0.416, 0.227, 0.376, 0.266, P<0.05), and negatively correlated with HDL-c and adiponectin levels (r=-0.410, -0.309, P<0.05). Leptin level was positively related to height for weight, FINS, HOMA-IR, LDL-C and chemokine levels (r=0.492, 0.375, 0.279, 0.269, 0.266, P<0.05), and negatively related to HDL-C and adiponectin (r=-0.467,-0.326,P<0.05). The level of adiponectin was negatively correlated with height for weight, FINS, HOMA-IR, LDL-c, chemerin and leptin (r=-0.296, -0.351, -0.278, -0.229, -0.309, -0.326, P<0.05), and positively correlated with HDL-c level(r=0.234, P=0.032). Conclusions The levels of serum chemerin, leptin and adiponectin are closely related to glucose and lipid metabolism in preschool simple obese children, which are of great significance for the identification, monitoring and intervention of preschool children with simple obesity. %U https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2021-1197