Table of Content

06 March 2012, Volume 20 Issue 3

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Analysis of genetic metabolic disease in high-risk infants screening in Xi'an area in 2010

AI Ting,LIU Li

2012, 20(3):  202-204. 

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【Objective】 To summary the incidence and the treatment experience of high-risk infants with congenital genetic metabolic disease in Xi'an region during 2010 year,and to promote clinical medical workers to improve their power of understanding and processing to congenital genetic metabolic disease. 【Method】 The technology of high performance liquid chromatography tandem mass spectrometry (HPLC/MS/MS) were used to screen 104 blood samples from high risk cases from 17 hospital in Xi'an area during 2010. 【Results】 Seven of 104 patients (6.7%) were positive in our selective screening program, including three with methylmalonic acidemia,one with transient tyrosinemia, one with homocystinuria,one with maple syrup urine disease(MSUD),and one with medium chain acyl-CoA dehydrogenase deficiency (MCAD). 【Conclusions】 The incidence of congenital genetic metabolic disease is very high in high-risk infants in Xi'an.According to the incidence,they are in turn to the organic acids metabolic disease,the amino sour metabolic disease and the lipid metabolic disease.Early screening is favorable not only for children and family to early intervention,also be helpful for hospital diagnosed etiology and reduce the occurrence of medical dispute it should deserve further promotion activities.

Analysis of interlaboratory quality survey in newborn screening for G6PD

WANG Wei,ZHONG Kun,HE Fa-lin,JIANG Yu,ZHANG Yan,WANG Zhi-guo

2012, 20(3):  205-207. 

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【Objective】 To investigate the test capability of G6PD for newborn screening laboratories. 【Methods】 According to China National Standard GB/T20470-2006 the requirements for external quality assessment (EQA) in clinical laboratory,2 of lots of G6PD dry blood filter paper for the first time and 5 for the second were sent to 58 and 70 newborn screening laboratories respectively.The feedback information which had been statistically analysed,included: results of G6PD quantitative test (unit:U/gHb),clinical judgment (Positive-negative),resources and information of cut off value.The capability of every laboratory that sent valid information had been evaluated. 【Results】 The valid feedback rate were 86.2% (50/58) and 74.3% (52/70) respectively.Stratified study by reagents indicated that the dispersions of every lot were significant large,for all the 7 lots the CVs (Coefficient of variations) were from 10.67% to 26.77% for that first time but 69.17% to 89.92% for another;robust CVs were from 5.38% to 44.00% and 102.37% to 144.99%.The pass rate of qualitative test were 91.7% and 94.0% respectively which were really much higher than quantitative test whose pass rate were only 53.7% and 74.5%. 【Conclusion】 Because of the large CVs and low pass rate,external quality control program for G6PD are intensively needed in order to improve newborn screening laboratories` test capability and then improve the quality of the population born in China.

Classification and treatment effect evaluation and genetic analysis of hyperphenylalaninemia in Shandong

ZOU Hui,HAN Bing-juan,PU Xiao-ping,TIAN Li-ping

2012, 20(3):  208-210. 

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【Object】 To discuss the classification and treatment effect evaluation and genetic analysis of hyperphenylalaninemia(HPA) in Shandong. 【Mthods】 396 cases of HPA diagnosed by newborn screening in Jinan Classified according to BH4 loading test and urine pterin analysis.Different treatments were given and mornitor the concentration of Phe.The treatment effect was evaluated by the body development and mental development. 【Result】 Among 396 cases of HPA, 356 of them were PAHD,40 cases of BH4D,128 cases of BH4 responsed PAHD.There was no statistically significant difference between the different types of HPA patients and normal children by the body development,including weight and height.132 cases of HPA patients had normal mental development among 155 HPA.IQ of classical PKU( PAHD) showed negative correlation with the concentration of phe.IQ of BH4D patients corresponded with the diagnosed time.There were 6 gene mutation among 11 BH4D patients.42.1% of them were 259C>T. 【Conclusions】 The different clinic and biochemical HPA patients have no statistically significant difference for the body development after treatment while they have statistically significant difference for the intelligence development.The intelligence development level for Classical PKU corresponded with the concentration of Phe while that for BH4D corresponded with the diagnosed time.259C>T is the most common mutation of BH4D.

Study on early clinical diagnosis of gastrointestinal perforation in preterm neonates

LIU Yun-feng,LI Zai-ling,LIU Li-juan,TONG Xiao-mei,PIAO Mei-hua,MA Ji-dong

2012, 20(3):  211-213. 

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【Objective】 To explore the early clinical diagnosis of gastrointestinal perforation in preterm neonates. 【Methods】 Ten cases of premature gastrointestinal perforation were registered in five years.Based on their general conditions,the incidence time,early clinical manifestation,diagnostic methods and prognosis of gastrointestinal perforation and possible precipitating factor of perforation,the early clinical diagnosis of gastrointestinal perforation in preterm neonates were analyzed. 【Results】 1)Totally,there were ten cases (6 males) with the average gestational age of 32 weeks,average body weight of 1 555 g,which included five small gestational age (SGA) perterms and 7 babies were one of the twin infants (7/10).2)Perforation occurred during 9 hours to 70 hours after birth (average=26 hours).The first clinical symptoms of the perforation were vomiting and abdominal distension;typical clinical manifestation appearance time was from 18 hours to 96 hours after birth (average=48 hours).The typical clinical manifestations included abdominal distension,high tension,abdominal wall pallidness,bowel sounds disappearence.The abdominal orthostatic X-ray images showed a great quantity of free gas under the flat diaphragm,declined liver bound,and abdominal paracentesis in some cases.Two cases were with good post-surgical outcomes and 7 cases died (mortality=7/9);1 case was lost of following-up.3)Induce factors of the gastrointestinal perforation:infection followed by gastrointestinal perforation (2/10);spontaneous gastrointestinal perforation (8/10);gastrointestinal perforation followed by infection (6/8).Six cases began to feed before onset symptoms appeared.Five cases had noninvasive ventilator before gastrointestinal perforation (5/10). 【Conclusions】 Small gestational age and low birth weight are high-risk factors of the gastrointestinal perforation.One to two days after birth and during severe infection is the high-risk occurrence time.Vomiting and/or abdominal distension are the first clinical symptoms in premature infants with perforation.Congenital poor growth in digestive tract is the foundation of perforation in premature infants.Infection,feeding and noninvasive ventilation may be precipitating factors.Once above-mentioned conditions appear in premature infants,we should be precautious about the gastrointestinal perforation in clinic.

Analysis of perinatal risk factors for early neonatal death among very low birth weight infants

LI Yue-feng,ZHOU Ping,WU Xiang-lan,CHEN Rui,LU Guang-jin

2012, 20(3):  214-217. 

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【Objective】 To investigate the relationship between perinatal risk factors and early neonatal death among very low birth weight (VLBW) infants. 【Methods】 A retrospective cohort of 143 VLBW infants admitted to NICU was studied.The dependent variable was the outcome,either survival or death at 7 days of life.The independent variables were assigned into three levels:distal,intermediate and proximal according to hierarchical model.All variables were subjected to univariate analysis and multivariate logistic regression. 【Results】 Early neonatal mortality was 13.29% (19/143) in VLBW infants.After the adjustment of variables through multivariate Logistic regression it showed that infants born to mother with cord prolapse had higher risk exposure for early death than those of mother without cord prolapse in the distal level (AOR:8.69;95%CI:1.128~67.002).At the intermediate level,infants with gestational age (GA)<28 weeks and 5-min Apgar scores<7 had higher odds of early death than those of GA≥28 weeks and 5-min Apgar scores≥7 (AOR:11.47,13.55;95%CI:2.066~63.712,3.156~58.221 respectively).At the proximal level,infants with intracranial hemorrhage (ICH) had higher risk of early death than those without ICH (AOR:4.56,95%CI:1.088~19.170). 【Conclusions】 The early neonatal mortality among VLBW infants is still high and continues to be a significant public health problem.Asphyxia at birth is the highest risk factor of early neonatal death.Reducing birth asphyxia through enhancing obstetric quality and strengthening cooperation between obstetric and neonatology department is still the key to decrease early neonatal death of VLBW infants.

Study on correlation between adverse outcome hypertension disorder complicating pregnancy and umbilical artery flow of fetus

WANG Zhi-ming,ZHUANG Ru-jin,HAN Cong-hui,YUAN Hong-wei,CHEN Su-fen,QIAO Su-zhen,XIE Ya-chun,FU Zhi-wei,GUO Lin,ZONG Yu-xi,ZHANG Hui-ying

2012, 20(3):  218-220. 

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【Objective】 To study the impact of hypertension disorder complicating pregnancy(HDCP) on pregnancy outcome and to investigate the relationship between index of umbilical artery blood flow and pregnancy adverse outcomes. 【Method】 A prospective survey of 57 HDCP patients and 59 normal pregnant women were selected,the perinatal outcomes were observed,and the index of fetal growth and umbilical artery blood flow were recorded. 【Results】 In the incidence rates of neonate asphyxia,premature labor,fetal low birth weight,and the index of umbilical artery blood flow,HDCP group were significantly higher than those of normal group(P<0.05).Between umbilical artery blood flow and pregnancy outcomes,there was a significant negative correlation. 【Conclusions】 Adverse pregnancy outcomes and abnormal umbilical artery blood flow indices are more likely to appear in HDCP mothers. Indices of uterine artery flow can predict the occur of adverse pregnancy outcomes.

Reliability and validity of the Network of Relationship Inventory-Relationship Quality Version in Chinese teacher-student relationship

KONG Zhen,CAO Feng-lin,CUI Nai-xue,LI Yang,CHEN Qian-qian,LIU Jia-jia

2012, 20(3):  221-223. 

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【Objective】 To assess the reliability and validity of Chinese children version of Network of Relationship Inventory-Relationship Quality Version (NRI-RQV). 【Method】 The original English version was translated into Chinese and administered to 822 children for teacher-student relationship quality assessment. 【Results】 The Cronbach α was 0.84 and the test-retest reliability was 0.77.Limited number of factors to 2,PCA shows the percentage of variance explained 39.86%.Confirmatory factor analysis showed that the fit indexes:χ²/df,RMSEA,GFI,AGFI,NNFI,CFI were 3.42,0.09,0.78,0.74,0.89,0.90. 【Conclusion】 The NRI-RQV is found to have good psychometrics properties, and applicable to assess the quality of Chinese parent-child relationship.

Prevalence of overweight and obesity among children and adolescents with 7~18 years in Xi'an urban area in 2009

CHANG Ming,XIAO Yan-feng,YIN Chun-yan,YI Xiao-qing,XU Er-di

2012, 20(3):  224-227. 

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【Objective】 To investigate the current prevalence of overweight and obesity among children and adolescence in Xi'an urban area. 【Methods】 13 994 students with 7~18 years were investigated prevalence overweight and obesity using random cluster sampling method.The overweight and obesity were defined with according to body mass index(BMI) criteria.Cubic smoothing spline was used to directly calculated weight,height and BMI of children and adolescents aged 7~18 years in Xian urban.P₅₀ of weight and height,P₈₅ and P₉₇ of BMI were compared to China standard curves in 2005. 【Results】 The incidence of overweight children with 7~18 years was 10.42%,those of boys and girls were respectively 11.85% and 8.83%.The incidence of obesity children with 7~18 years was 4.67%,those of boys and girls were respectively 4.92% and 4.40%.The centile curves of P₅₀ of weight for boys and girls,height for girls were similar with that of China standardization curves height and weight of children with 0~18 years in 2005.The centile curves of P₅₀ of height for boys with 10~15 years was a little lower than those of China standardization curves.The centile curves of P₈₅,P₉₅ of BMI for boys were similar with that of China standardization curves.The centile curves of P₈₅,P₉₅ of BMI for girls below 14 years were similar with that of China standardization curves, but that of after 15 years was a little lower than China standardization curves. 【Conclusions】 The incidence of obesity students with 7~18 years in Xi'an doubled within 17 years.The effective precautionary measures of overweight and obesity among children and adolescence are the necessary tideway of the situation.

Epidemiological study on health and influencing factors of the small for gestational age infants

ZHU Jie,MA Jun,XU Ping,LIU Xiang-mei

2012, 20(3):  228-230. 

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【Objective】 To study the birth rate,health,complications,mortality of small for gestational age (SGA) infants and influencing factors,so as to provide evidence for caring SGA infants in the department of obstetrics,pediatrics and child healthcare. 【Methods】 Data of all newborns born in Beijing Haidian Maternal and Child Health Hospital were collected for statistical analyses from January 1,2006 to December 31,2007.The 217 SGA infants were selected as the case group.The appropriate for gestational age (AGA) infants who were born on the first day of every month were randomly selected as the comparison group.The complications and maternal infections,pregnancy-induced hypertension,diabetes,anemia,premature placenta,etc.were analyzed. 【Results】 In the 22 752 infants born from 2006 to 2007,217 infants were SGA.The birth rate of SGA infants was 0.95%.The incidence rate of complications of SGA infants from high to low were:hyperbilirubinemia (31.3%),respiratory diseases (10.6%),anemia (5.5%),hypoglycemia (5.1%),digestive diseases (4.6%).The SGA infants had significantly higher incidence rate of complications than those AGA infants (P＜0.05).Pregnancy-induced hypertension,abnormality of umbilical cord,premature rupture of membranes and twin were the major factors associated with SGA.The mortality of SGA was 1.4%,higher than that of AGA (0.14%) and total newborn mortality (0.15%),with statistically significant difference(P＜0.05). 【Conclusion】 The factors such as pregnancy-induced hypertension was the major factor associated with SGA.SGA had higher incidence rate of complications and mortality,who should be paid attention in further prevention and scientific care.

Study of hippocampal neuronal ultrastructures and synaptic morphology in filial rats with maternal lead exposure in pregnancy

ZHOU Jian-ping,WANG Fan,HUANG Jian-feng,ZHANG Jun,YANG Yu-feng,YANG Lin

2012, 20(3):  231-234. 

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【Objective】 To explore the possible mechanism of learning and memory impairment in filial rats with lead exposure of mother pregnant rats by observing the ultrastructural pathologic changes of hippocampal neurons and organelles, and the features of synaptic morphological parameters. 【Methods】 Female pregnant Spraque-Dawley (SD) rats were divided into high dose lead exposure group(HG) and low dose lead exposure group(LG) by drinking 0.1% or 0.2% lead acetate dissolved by three distilled water,the normal control group(NG) pregnant rats drank three distilled water.36 days after birth, transmission electron microscope were used to examine the ultrastructural pathologic changes of neurons and organelles,and the features of synaptic morphological parameters of hippocampal CA1 area in 9~12 male filial rats from HG,LG or NG group. 【Results】 Severe ultrastructural pathologic changes were found in hippocampal CA1 area of filial rats with lead exposure of mother pregnant rats.The changes of neuronal degeneration and necrosis,mitochondria swelling,polyribosomes disaggregation from endoplasmic reticulum,and golgiosomes dilation in lead exposure group were more significantly severe than those of the control group(P<0.05 or <0.01).Compared with the control groups, lead exposure group showed significant decreases of postsynaptic density thickness,synaptic active zone length,and synaptic interface curvature,as well as significant increases of synaptic cleft (all P<0.01) .In addition, lead exposure group showed no significant differences in synaptic numeric density and synaptic surface density as compared with the control groups. 【Conclusions】 Lead exposure of pregnant rat could result in severe ultrastructural pathologic chandes of neurons and organells,as well as the significant synaptic plasticity in hippocampal areas of filial rats.The possible mechanism of learning and memory impairment in filial rats with lead exposure of mother pregnant rats is also relative to these pathologic changes.

Analysis of Guangxi congenital hypothyroidism newborn screening and discussion the cutoff value

FAN Xin,CHEN Shao-ke,LIN Cai-juan,LI Wang,FENG Shi-han,LUO Jing-si,QIAN Jia-le,GUO Xiao-fang,LI Zheng,HE Chun-yu

2012, 20(3):  248-250. 

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【Objective】 In order to know the distribution of TSH and incidence of congintal hypothroid newborns in Guangxi provinces,and study the cutoff for newborn screen. 【Method】 The dates of newborn screen centre of Guangxi Zhuang Autoumous Region were analyzed,which was about 270 590 neonatals,and calculated the TSH cutoff by percent and ROC curve,then,analyzed the complexion of sufferers by different cutoff. 【Results】 The distribution of newborn screen was deflection,P₅₀ was 1.89 mU/L,P₉₉ was 8.13 mU/L,combined with ROC curve,the cutoff of our lab was 8.1 mU/L. 【Conclusion】 Different cutoff effect the consequences of newborn screen.To establish establish the suitable cutoff based on lab is important.

Cytogenectical analysis of 329 childen cases with neurological dysplasia

DING Ying-xue,ZOU Li-ping,CHEN Ying,ZHANG Li-ping,XIAO Jing,ZHENG Hua,CUI Hong

2012, 20(3):  251-253. 

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【Objective】 To investigate the types and proportion of chromosomal abnormalities in patients with neurological dysplasia and pregnant women under 30 years old. 【Method】 329 cases,who were diagnosed neurological dysplasia and mother reproductive age less than 30 years old,were performed by karyotype analysis of peripheral blood. 【Results】 Among 329 cases,245 cases were found abnormal karyotype ( 74.5% ) .The percentage of euchromosome abnormalities was 85% (208 cases),including 190 cases of number abnormalities (190/245,36.7% ) and 18 cases of structure abnormalities (18/245,7.35% )from which 184 cases were Down syndrom,6 cases were 22 trisomy,the abnormal rate of boys was much higher than that of girls,boys∶girls=2.06∶1 .The percentage of sex chromosome abnormalities was 15 % ( 37 cases),including 9 cases of number abnormalities (9/245,3.67 % ),28 cases of structure abnormalities (28/245,11.4%);Of which the most common karyotype was fragil X syndrome,total 28 cases.Klinefelter syndrome was the common number abnormalities,karyotype 47,XXY( 4 cases);the main aneuploid forms of sex chromosome were 47,XYY(3 cases ),47,XXX(1 case ),49,XXXY(1 case ). 【Conclusion】 Down syndrome is still a common chromosomal abnormality among pregnant women under 30 years old.

Aggregate analysis for eye-disease screen in 8 002 neonates

ZHANG Min,ZHANG Lin-na,GUO Yu-luan,DONG Yan-ru,YIN Su-ying,SHI Jin-na

2012, 20(3):  254-256. 

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【Objective】 To explore the screening method to neonatal and the incidence inborn eye-diseases. 【Methods】 The neonates accepted eye-disease screen including examination to external eye and reflection to red light,who were born in Jinan maternal and child health care hospital from Jan-01,2010 to Nav-30,2010.The following examination to eyeground after mydriasis were used to the neonates who were abnormal in the above two examination and the high risk infants. And then analysed the result. 【Results】 8 002 neonates accepted eye-disease screen.The rate of eye-diseases in neonate were 13.93%.Of the rate of inborn eye-diseases was 0.67% (54 cases) and the rate of acquired eye-diseases was 13.26% (1 061 cases). 【Conclusion】 There are high incidence of neonatal eye-diseases,so the screening in neonate is much significant to clinical practices.

Analysis of monitoring results for birth defects in Shaanxi province from 2006 to 2010

LI Pan,ZHOU Xiao-juan,GAN Lu,YANG Yang

2012, 20(3):  259-263. 

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【Objective】 To investigate the incidence and epidemiologic characteristics of birth defects in Shaanxi province,then to provide scientific evidences for the key of future work. 【Methods】 All perinatal infants aged from 28 weeks of gestation to 7 days after birth in 25 monitoring hospitals in Shaanxi province from 2006 to 2010 were monitored for birth defects.The data were entered by Excel 2003 and analyzed by SPSS 13.0 software. 【Results】 The incidence of birth defects in Shaanxi province from 2006 to 2010 was 117.8 per 10 000.There was an annual ascending tendency in incidence of birth defects(χ²=16.81,P<0.01).The first five main birth defects were total cleft lip,neural tube defects,congenital heart diseases,polydactyly,congenital hydrocephalus,respectively.The incidence of congenital heart diseases showed a year by year ascending trend(χ²=8.58,P<0.01).The incidence of birth defects in rural areas was significantly higher than that in urban area(χ²=70.72,P<0.01). Single defects took up 83.5%.There were 52.2% cases diagnosed by ultrasound and 45.9% cases diagnosed by clinical.The Prenatal diagnosis rate was 48.1%.The perinatal mortality rate was 8.3‰ and showed a year by year descending trend(χ²=6.91,P<0.01).During the five years,the mortality among defective perinatal infants was significantly higher than that among non-defective perinatal infants,and the incidence of birth defects among dead perinatal infants was also significantly higher than the incidence of other cause of death. 【Conclusions】 The incidence of birth defect in Shaanxi province from 2006 to 2010 is lower than the nationwide contemporary level.Much attention should be paid to reduce the incidence of birth defects in rural areas, carry out the preventive work of neural tube defect and improve the prenatal diagnosis ability of all monitoring hospitals.

Epidemiological and clinical characteristics of fatal cases of hand,foot and mouth disease in Shandong province in 2009-2010

NIU Wen-ke,DING Shu-jun,LIN Yi,WANG Lian-sen,PEI Yao-wen,SUN Da-peng,WANG Jian-xing,PANG Bo,JIANG Bao-fa,WANG Xian-jun

2012, 20(3):  263-266. 

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【Objective】 To analyze the epidemiologic and clinical features of 53 fatal cases of hand, foot and mouth disease(HFMD) in Shandong province in 2009-2010,so as to provide scientific basis for reducing mortality and optimizing treatments for severe cases. 【Methods】 Epidemiological investigations and laboratory tests were carried out on these fatal cases,and descriptive epidemiology was used to analyze acquired information. 【Results】 The average age of fatal cases was 1 year 6 months,and cases under 2-year-old accounted for 83.0%.The number of deaths from rural areas was larger than that of urban areas.The death ratio between male and female was 3.4∶1.Death cases were dominated by EV71 infection(13/15),with the average course (82.4±4.7) h.96.9% cases had fever from onset,then rash occurred after 1.06 days.Most cases also had other clinical manifestations, such as convulsion,irritability,lethargy,myoclonic twitching,short of breath,dyspnea,respiratory rhythm changes,pink foaming from mouth,lung moist rale,cardiac rhythm changes or vomiting.Primary causes of death was ranked as neurogenic pulmonary edema (96.9%),encephalitis (65.6%) or respiratory and circulatory failure (46.9%). 【Conclusions】 Death cases under 2-year-old had shorter course and higher case fatality rate. In order to reduce deaths of HFMD,it is of vital importance to strengthen monitoring of severe patients, to enhance the ability of early recognition and sensitivity of severe clinical manifestations,to take treatment earlier and to slow down the progression of the disease.

Antenatal diagnosis and prognosis evaluation of fetal hydronephrosis

ZHOU Li-ping ,ZHANG Tan

2012, 20(3):  267-269. 

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【Objective】 To discuss the antenatal sonographic diagnosis of fetal hydronephrosis and to evaluate the prognosis of them.Then to provide help for clinical intervention. 【Methods】 72 fetuses(91 kidneys)received B ultrasound when they were 18~40 weeks pregnant.The anteroposterior diameter and thickness of parenchyma were noted and compared.They were divided into 3 groups,mild,moderate and severe according to the anteroposterior diameter of pyelectasis, then were followed up visitation at special time. 【Results】 In group of mild hydronephrosis,there were 42 kidneys whose hydronephrosis disappeared,4 eased or had no change and 2 aggravated.However,in the group of moderate hydronephrosis,there were 15 kidneys whose hydronephrosis disappeared,2 eased or have no change and 9 aggravated.There were 8 kidneys with the parenchymal thickness less then 5 mm in this group,and 4 of them were operated.And in the group of severe hydronephrosis,2 kidneys whose hydronephrosis eased or have no change and 15 aggravated.There were 11 kidneys with the parenchymal thickness less then 5 mm in this group,and 5 of them were operated. 【Conclusion】 Most of the hydronephrosis with the anteroposterior diameter of renal pelvis less then 15 mm is a physiological change,which can disappear along with individual development.The fetal hydronephrosis which more then 15 mm and parenchymal thickness being less then 5mm shoud be obsevered periodically.If the hydronephrosis remain stabilized or become more severe,we must pay more attention or peform the operation.

Correlation of infant feeding index of 6~12 month-old and iron nutritional status from east Cixi district

JIANG Ya-li,HUA Xu-dan,RU Na-dan

2012, 20(3):  269-272. 

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【Objective】 To explore the correlation of infant feeding index of 6~12 month-old and nutritional status from east Cixi district,Zhejiang province. 【Method】 A total of 355 infants aged 6~12 months were evaluated by Chinese Center for Disease Control Nutrition and Food Safety Feeding Index Score System and the correlation of feeding index and anemia, iron metabolism were analyzed. 【ResultS】 The average feeding index were (9.33±1.45) points,including 6~8 months group (9.51±1.64) points and 8~12 months group (9.17±1.35) points.6~8 months age group and 8~12 months age group with the ferritin in qualified group were significantly higher than the failed group (P<0.05), but not for hemoglobin concentration (P> 0.05) for both 6~8 month group and 8~12 month group.Moreover,the prevalences of iron deficiency in failed group were significantly higher than those of qualified group (P<0.05) but not for anemia for both 6~8 month group and 8~12 month group. 【Conclusion】 Infant feeding index score can accurately reflected iron and anemia status in east Cixi region infant,and it might be an early diagnosis index to provide a reliable evaluation.

Effects of Qingrejieduliangxuefang combined with montmorillonite powder on related factors of infectious diarrheal children

LI Jiang,LI Chun-fang,HUANG Mao,YANG Hui-rong,WU Fang,LI Hua-zhong

2012, 20(3):  272-274. 

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【Objective】 To probe the effects of IL-8,IL-10 and NF-kB about qingrejieduliangxuefang combined with montmorillonite powder to infectious diarrheal children. 【Methods】 All 162 outpatients and inpatients suffered with infectious diarrhea were enrolled randomly, but during the study,12 cases were exited because of uninsistence.So 150 cases were given to viral enteritis group and bacterial enteritis group,8 normal children were as normal group and the expression of related factors of pre-treated and post-treated were tested.Children were randomly divided into treated Ⅰgroup,treatedⅡgroup,and control group according to treated programs. Retention enema of qingrejieduliangxuefang was given to treatedⅠgroup,and combined with montmorillonite powder to treatedⅡgroup,montmorillonite powder was given to control group.The changes of related factors of pre-treated and post-treated for 5 days and 15 days were tested. 【Results】 Pre-treated,the IL-8 level was without significant difference(P>0.05) in bacterial enteritis and viral enteritis group.The IL-10 level of bacterial enteritis group was lower than that of viral enteritis group(P＜0.01).Pre-treated,the level of IL-8,IL-10 and NF-kB was without significant difference(P>0.05) in treatedⅠgroup,treatedⅡgroup,and control group.At the end of 5 days and 15 days,compared with oneself pre-treated,the expression of each group reduced signally(P＜0.01)and the level of treated Ⅱgroup was superior to treatedⅠgroup and control group(P＜0.05). 【Conclusions】 IL-10 is helpful to indentify bacterial enteritis and viral enteritis.Qingrejieduliangxuefang combined with montmorillonite powder is good to reduce the expression of related factors and promote a speedy recovery of infectious diarrheal children.

Massage combined with Vojta neurodevelopmental treatments for 88 cases of cerebral palsy clinical experience

LIU Mu-jin,LUO Xiang-yang,HE Zhan-wen,LI Ping-gan,LI Dong-fang,YAO Yuan-mian

2012, 20(3):  275-277. 

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【Objective】 To investigate the effect of massage combining Vojta therapy for cerebral palsy. 【Method】 88 cases of children with cerebral palsy were randomly divided into two groups,42 cases of the control group received traditional medicine rehabilitation including massage and acupuncture for three months,and 46 cases of the observation group received treatments of traditional rehabilitation combining Vojta therapy for three months.Vojta postural reflex test was used to evaluate the effect before and after treatment. 【Results】 The effective rate of the observation group was 95.7 %,while the control group was 76.2 %,difference between the two groups was statistically significant(P<0.05). 【Conclusion】 The treatment of massage combining Vojta therapy is effective for cerebral palsy.

Investigation of the common inducements of asthmatic exacerbation in children with asthma in Shijiazhuang area

FENG Ai-fang,LI Jin-ying

2012, 20(3):  277-279. 

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【Objective】 To investigate the common inducements of asthmatic exacerbation in Shijiazhuang area and the way to prevent children with asthma from them. 【Methods】 All children with asthma were divided into two groups,infantile group (<3 years ) and children group ( over 3 years) and analysed the common causes associated with which led to asthmatic exacerbation in children with asthma through the unified questionnaire survey.And analysed the common allergens through receiving skin prick test on 1 week after remission for the enrolled children. 【Results】 The first age of onset was mainly concentrated less than 6 years old,especially within 3 years old.Resporatory infection was mainly common inducement,the easily exacerbated seasons were autumn and winter,the easily exacerbated time was night and morning,93.5% in infantile group vs 54% in children guoup,which was significantly different in statistics (χ²=46.122,P<0.01).The other common cause was to quit to inhale corticosteroids or to reduce dosage of inhalation corticosteroids without suggestion by pediatrist,30.1% in infantile group vs 44.4% in children group,which was significantly different in statistics (χ²=4.952,P<0.05).Allergens in living entertainment led to asthmatic exacerbation,26.2% in infantile group vs 43.7% in children group,which was significantly different in statistics (χ²=7.497,P<0.05).Although sports were the important factor cause asthmatic exacerbation in children with asthma,there was no significantly different from both two groups in statistics (χ²=2.744,P>0.05).446 cases in total were positive in skin prick test with allergens,and the ratio was 96.3%.Positive in skin prick test with dust mite and willow pollen were the most common allergen,46.8% and 19.8% in infantile group,35.0% and 37.4% in children goup,significant difference found in statistics(χ²=5.417,12.849,P<0.01). 【Conclusions】 Respiratory infection is one of the most common causes led to asthmatic exacerbation in children especially infantile with asthma.Non-infection factors become the important cause led to asthmatic exacerbation in children with asthma when growth up.To reduce the risks of resporatory infection,keep out of allergens and inhale corticosteroids regulate are availabe ways to prevent children with asthma from asthmatic exacerbation.

Investigation of the reference values of serum cystatin C within healthy preschool children

ZHAO Li-hua,HE Qian,WANG Xiang-ling,AN Zhe,ZHANG Lei

2012, 20(3):  280-281. 

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【Objective】 To investigate the reference values of serum cystatin C within the healthy preschool children. 【Method】 The automatic biochemical analyzer(OLYMPUS AU2700)was used to detect the level of serum cystatin C of 474 healthy preschool children and 172 normal adults.Then the data were analyzed with statistical methods. 【Results】 The value of cystatin C of infant group, child care group,preschool group and normal adult group were 0.62~1.74,0.47~1.15,0.41~0.97 mg/L and 0.46~1.02 mg/L,respectively.Infant group,child care group and normal adult group reference values were significantly different (P<0.05).There was no difference between preschool group and normal adult group.Each of the groups were compared by sex,between boys and girls within each group of Cys C reference values were not significantly different (P>0.05).Normal adult reference range for the control group,infant group,child care group overrun detection rates were 56.8%,11.1%. 【Conclusions】 Infant group, child care group and adult group can adopt different reference values of serum cystatin C,preschool group and normal adult group can use the same.There is no difference between boys and girls for serum cystatin C.