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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (1): 110-117.doi: 10.12092/j.issn.1009-2501.2025.01.013

• 综述与讲座 • 上一篇    下一篇

急性肾损伤中巨噬细胞调控机制进展

段宇鑫,张燕妮,柏艺,俞瑾瑶,孙佳怡,王泽洁,李玲,叶啟发   

  1. 武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,国家人体捐献器官获取质量控制中心,移植医学技术湖北省重点实验室,武汉  430071,湖北

  • 收稿日期:2023-12-20 修回日期:2024-01-17 出版日期:2025-01-26 发布日期:2025-01-02
  • 通讯作者: 李玲,女,博士,副主任药师,研究方向:器官移植术后并发症的个体化基因研究。 E-mail:zn000426@whu.edu.cn
  • 作者简介:段宇鑫,女,研究方向:器官移植术后并发症的个体化基因研究。 E-mail:3287494707@qq.com
  • 基金资助:
    湖北省自然科学基金青年基金(2021CFB062);武汉大学基础-临床共建项目培育基金(JCZN2022006);中央高校基本科研业务费专项资金青年教师资助项目(2042023kf0064);武汉大学中南医院转化医学及交叉学科研究联合基金(ZNJC202319)

Progress of macrophage regulation mechanism in acute renal injury

DUAN Yuxin, ZHANG Yanni, BAI Yi, YU Jinyao, SUN Jiayi, WANG Zejie, LI Ling, YE Qifa   

  1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, Hubei, China
  • Received:2023-12-20 Revised:2024-01-17 Online:2025-01-26 Published:2025-01-02

摘要:

急性肾损伤(acute kidney injury,AKI)是一种以肾排泄功能迅速下降为特征的综合征,其发病机制尚不明确。研究表明,巨噬细胞是AKI炎症反应的主要参与者,调控组织的损伤和再生修复。AKI炎症期间巨噬细胞可通过分子及信号通路活化为不同功能表型,调控不同分子及信号通路,决定AKI的进展。本文综述了近五年来巨噬细胞活化及参与调控AKI的多种分子信号通路,确定巨噬细胞在AKI中的作用机制,为以巨噬细胞为治疗靶点的研究提供思路。

关键词: 急性肾损伤, 巨噬细胞感应介质, 巨噬细胞衍生介质, 信号通路

Abstract:

Acute kidney injury (AKI) is a syndrome characterized by rapid decline in renal excretory function. Its pathogenesis is still unclear. Studies have shown that macrophages are major players in AKI inflammation, regulating tissue damage and regeneration repair. During AKI inflammation, macrophages can be activated into different functional phenotypes through molecular and signaling pathways, regulate different molecules and signaling pathways, and determine the progression of AKI. In this paper, the activation of macrophages and the molecular signaling pathways involved in the regulation of AKI in the past five years are reviewed, and the mechanism of action of macrophages in AKI is determined, which provides ideas for the study of macrophages as therapeutic targets.

Key words: acute kidney injury, macrophage-sensing mediators, macrophage-derived mediators, signal pathway

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