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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (1): 118-124.doi: 10.12092/j.issn.1009-2501.2025.01.014

• 综述与讲座 • 上一篇    下一篇

褪黑素在脓毒症治疗中的研究进展

李楠1,唐婉春2,张忠齐1,左祥荣1   

  1. 1南京医科大学第一临床医学院,南京  210009,江苏;2南京医科大学第一附属医院重症医学科,南京  210009,江苏

  • 收稿日期:2024-02-28 修回日期:2024-05-16 出版日期:2025-01-26 发布日期:2025-01-02
  • 通讯作者: 左祥荣,男,医学博士,教授,主任医师,硕导,研究方向:重症医学的基础与临床研究。 E-mail:13913979197@139.com
  • 作者简介:李楠,女,硕士,住院医师,研究方向:重症医学相关危重症疾病的临床研究。 E-mail:2183932528@qq.com
  • 基金资助:
    江苏省333人才工程项目(2022-3-25-045);中华国际医学交流基金会中心血管多学科整合思维研究基金

Research progress in the study of melatonin in the treatment of sepsis

LI Nan1, TANG Wanchun2, ZHANG Zhongqi1, ZUO Xiangrong1   

  1. 1 First Clinical School of Nanjing Medical University, Nanjing 210009, Jiangsu, China; 2 Department of Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu, China
  • Received:2024-02-28 Revised:2024-05-16 Online:2025-01-26 Published:2025-01-02

摘要:

脓毒症因其高患病率、高死亡率和高治疗费用以及缺乏有效的救治手段而使它成为人类健康的巨大威胁。研究发现褪黑素作为昼夜节律的主要调节激素,具有抗炎、抗氧化、免疫调节、线粒体保护和多器官功能保护作用,可能是一种防治脓毒症非常有前途的药物。本文从褪黑素在脓毒症治疗和多器官功能保护方面的作用机制及临床疗效的研究进展进行综述,以期为脓毒症的研究和治疗,提供更多思路和帮助。

关键词: 脓毒症, 褪黑素, 多器官功能障碍综合征, 器官保护

Abstract:

Sepsis poses a significant threat to human health due to its widespread prevalence, high mortality rate, substantial treatment costs, and the absence of effective life-saving therapies. Melatonin, a primary hormone regulating the circadian rhythm, has demonstrated potential as a promising therapeutic agent against sepsis. Its anti-inflammatory, antioxidant, immunomodulatory, mitochondrial protective, and multi-organ protective effects are noteworthy. In this review, we summarize current research on the mechanisms of action and clinical efficacy of melatonin in sepsis treatment and multi-organ function preservation, aiming to offer new perspectives and support for sepsis research and therapy.

Key words: sepsis, melatonin, multiple organ dysfunction syndrome, organ protection

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