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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (1): 125-130.doi: 10.12092/j.issn.1009-2501.2025.01.015

• 综述与讲座 • 上一篇    下一篇

阿片类药物对阻塞性睡眠呼吸暂停的影响研究进展

孙静梓1,刘维英2,胡澳燕1,鲍八虎1,叶育才1,陈国荣1   

  1. 1兰州大学第一临床医学院,兰州  730030,甘肃;2兰州大学第一医院呼吸与危重症医学科,兰州  730030,甘肃

  • 收稿日期:2024-01-24 修回日期:2024-03-19 出版日期:2025-01-26 发布日期:2025-01-02
  • 通讯作者: 刘维英,女,博士,主任医师,硕士生导师,研究方向:睡眠呼吸暂停与慢性间歇缺氧。 E-mail:lwy70828@126.com
  • 作者简介:孙静梓,女,硕士,研究方向:阻塞性睡眠呼吸暂停,慢性阻塞性肺疾病。 E-mail:s1125531196@163.com
  • 基金资助:
    甘肃自然科学基金(21JRIRA074)

Research progress on the effect of opioids on obstructive sleep apnea

SUN Jingzi1, LIU Weiying2, HU Aoyan1, BAO Bahu1, YE Yucai1, CHEN Guorong1   

  1. 1 The First Clinical Medical College of Lanzhou University, Lanzhou 730030, Gansu, China; 2 Department of Respiratory and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou 730030, Gansu, China
  • Received:2024-01-24 Revised:2024-03-19 Online:2025-01-26 Published:2025-01-02

摘要:

阻塞性睡眠呼吸暂停(OSA)是一种以慢性间歇性缺氧和睡眠片段化为特征的疾病,通常表现为上呼吸道的阻塞,导致睡眠片段化、间歇性缺氧和高碳酸血症。OSA及显著的合并症与围手术期并发症易发有关,阿片类药物作为最常用的止疼药,可能进一步影响OSA及合并症患者围手术期疼痛管理,研究表明,OSA患者更容易受到阿片类药物的呼吸抑制作用的影响,反过来,OSA也增加了阿片类药物诱导的呼吸抑制的风险。因此,了解阿片类药物对OSA的影响及机制,对于优化药物使用、改善预后、减少呼吸不良事件有重要的临床意义。本文拟对阿片类药物对OSA的影响及其关系作一综述。

关键词: 阻塞性睡眠呼吸暂停, 阿片类药物

Abstract:

Obstructive sleep apnea (OSA) is a disorder characterized by chronic intermittent hypoxia and sleep fragmentation, usually manifested by obstruction of the upper respiratory tract, resulting in sleep fragmentation, intermittent hypoxia, and hypercapnia.OSA and significant comorbidities are associated with perioperative complications. Opioids, as the most commonly used pain relievers, may further affect perioperative pain management in OSA and comorbidities. Studies have shown that OSA patients are more susceptible to the respiratory depressant effects of opioids.OSA also increases the risk of opioid-induced respiratory depression.Therefore, understanding the effects and mechanisms of opioids on OSA has important clinical significance for optimizing drug use, improving prognosis, and reducing respiratory adverse events.This article aims to review the effects of opioids on OSA and their relationship.

Key words: obstructive sleep apnea, opioids

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