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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (2): 193-199.doi: 10.12092/j.issn.1009-2501.2025.02.005

• 消化系统肿瘤靶向治疗进展及前沿专栏 • 上一篇    下一篇

抗血管生成靶向药物在治疗结直肠癌的耐药机制研究进展

蒋海涛,许阳贤   

  1. 上海中医药大学附属龙华医院普外二科,上海  200032
  • 收稿日期:2024-08-09 修回日期:2024-10-08 出版日期:2025-02-26 发布日期:2025-02-05
  • 通讯作者: 许阳贤,男,医学硕士,主任医师,博士生导师,研究方向:中西医结合防治胃肠道肿瘤。 E-mail: xuyangxian@163.com
  • 作者简介:蒋海涛,男,医学硕士,主治医师,研究方向:中西医结合防治胃肠道肿瘤。 E-mail: jht_9056@sina.com
  • 基金资助:
    上海市自然科学基金面上项目(22ZR1462000);上海中医药大学附属龙华医院第四批龙医学者(Y21021);上海市中医肿瘤临床医学中心(21MC1930500)

Research progress on the resistance mechanism of anti-angiogenesis targeted drugs in the treatment of colorectal cancer 

JIANG Haitao, XU Yangxian    

  1. Department of General Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China
  • Received:2024-08-09 Revised:2024-10-08 Online:2025-02-26 Published:2025-02-05

摘要: 结直肠癌(CRC)是全球范围内的高发恶性肿瘤之一,尽管抗血管生成靶向药物如贝伐珠单抗在治疗转移性CRC中显示出显著疗效,但耐药性的出现仍然是影响患者治疗成功率和生存期的关键障碍。本文综述了抗血管生成靶向药物在CRC治疗中的研究进展、耐药机制以及如何解决耐药性的研究进展。

关键词: 结直肠癌, 抗血管生成, 耐药机制, 靶向治疗

Abstract:

Colorectal cancer (CRC) is one of the most common malignancies worldwide, although anti-angiogenic targeted agents such as bevacizumab have shown significant efficacy in the treatment of metastatic CRC, however, the emergence of drug resistance is still a key obstacle affecting the success rate of treatment and survival of patients. This article reviews the progress of anti-angiogenesis targeted drugs in the treatment of CRC, the mechanism of drug resistance and how to solve the problem of drug resistance. 

Key words: colorectal cancer, anti-angiogenesis, mechanism of drug resistance, targeted therapy

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