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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2025, Vol. 30 ›› Issue (1): 110-117.doi: 10.12092/j.issn.1009-2501.2025.01.013

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Progress of macrophage regulation mechanism in acute renal injury

DUAN Yuxin, ZHANG Yanni, BAI Yi, YU Jinyao, SUN Jiayi, WANG Zejie, LI Ling, YE Qifa   

  1. Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, Hubei, China
  • Received:2023-12-20 Revised:2024-01-17 Online:2025-01-26 Published:2025-01-02

Abstract:

Acute kidney injury (AKI) is a syndrome characterized by rapid decline in renal excretory function. Its pathogenesis is still unclear. Studies have shown that macrophages are major players in AKI inflammation, regulating tissue damage and regeneration repair. During AKI inflammation, macrophages can be activated into different functional phenotypes through molecular and signaling pathways, regulate different molecules and signaling pathways, and determine the progression of AKI. In this paper, the activation of macrophages and the molecular signaling pathways involved in the regulation of AKI in the past five years are reviewed, and the mechanism of action of macrophages in AKI is determined, which provides ideas for the study of macrophages as therapeutic targets.

Key words: acute kidney injury, macrophage-sensing mediators, macrophage-derived mediators, signal pathway

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