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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2025, Vol. 30 ›› Issue (1): 125-130.doi: 10.12092/j.issn.1009-2501.2025.01.015

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Research progress on the effect of opioids on obstructive sleep apnea

SUN Jingzi1, LIU Weiying2, HU Aoyan1, BAO Bahu1, YE Yucai1, CHEN Guorong1   

  1. 1 The First Clinical Medical College of Lanzhou University, Lanzhou 730030, Gansu, China; 2 Department of Respiratory and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou 730030, Gansu, China
  • Received:2024-01-24 Revised:2024-03-19 Online:2025-01-26 Published:2025-01-02

Abstract:

Obstructive sleep apnea (OSA) is a disorder characterized by chronic intermittent hypoxia and sleep fragmentation, usually manifested by obstruction of the upper respiratory tract, resulting in sleep fragmentation, intermittent hypoxia, and hypercapnia.OSA and significant comorbidities are associated with perioperative complications. Opioids, as the most commonly used pain relievers, may further affect perioperative pain management in OSA and comorbidities. Studies have shown that OSA patients are more susceptible to the respiratory depressant effects of opioids.OSA also increases the risk of opioid-induced respiratory depression.Therefore, understanding the effects and mechanisms of opioids on OSA has important clinical significance for optimizing drug use, improving prognosis, and reducing respiratory adverse events.This article aims to review the effects of opioids on OSA and their relationship.

Key words: obstructive sleep apnea, opioids

CLC Number: