关键词: 降钙素原, 早产儿, 呼吸机相关性肺炎
中图分类号:R749.94 文献标识码:A 文章编号:1008-6579(2015)08-0843-04 doi:10.11852/zgetbjzz2015-23-08-19

Abstract: Objective To evaluate the diagnostic value of procalcitonin (PCT) in premature ventilator-associated pneumonia (VAP). Methods 126 cases of preterm infants were divided into mechanical ventilation group and non mechanical ventilation group(the control group).81 preterm infants on ventilators were divided into VAP group and non-VAP group depending on whether the patients developed VAP.The levels of blood PCT,C-reactive protein (CRP) and the white blood cell (WBC) of preterm infants with mechanical ventilation group before the mechanical ventilation and after 48 hours were retrospectively analyzed,and compared with the control group. Results There were no significant differences of PCT,WBC,CRP in the VAP group,non-VAP group and the control group before mechanical ventilation (P>0.05).At 48 hours after mechanical ventilation,there were no significant differences of WBC in three group (P>0.05).But there was not all equal of PCT or CRP between the three groups,and the PCT and CRP showed obvious difference in VAP group compared with non-VAP group and the control group( all P<0.000 ),and there were no significant differences of PCT and CRP in non-VAP group and the control group (P>0.05).The area under the curve (AUC) of receiver-operation characteristics (ROC) was 0.936 for PCT and 0.702 for CRP to diagnose premature ventilator-associated pneumonia,there was significant differences (P=0.000). Conclusion The PCT for early diagnosis of neonatal VAP has higher accuracy than CRP and WBC.

Key words: procalcitonin, preterm infants, ventilator-associated pneumonia