Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (5): 516-520.DOI: 10.11852/zgetbjzz2022-1081

• Review • Previous Articles     Next Articles

Research advances on the correlation of gene polymorphisms of vitamin D receptor and vitamin D level with neurodevelopmental disorders in children

LI Jia, ZHANG Yanchi   

  1. Department of Clinical Pharmacy,Changchun Sixth Hospital,Changchun,Jilin 130000,China
  • Received:2022-09-03 Revised:2023-01-04 Online:2023-05-10 Published:2023-05-06
  • Contact: ZHANG Yanchi,E-mail:


李嘉, 张延赤   

  1. 长春市第六医院临床药学部,吉林 长春 130000
  • 通讯作者: 张延赤,
  • 作者简介:李嘉(1987-),女,吉林人,副主任药师,硕士学位,主要研究方向为精神科药物基因组学和儿童发育障碍及行为问题。
  • 基金资助:

Abstract: Vitamin D and its receptors (VDR) are widely expressed in various regions of human body.VDR mediates all molecular effects of active vitamin D, and its gene polymorphisms have been linked to a variety of neurodevelopmental disease.This article reviews the association of vitamin D and VDR gene polymorphisms with childhood neurodevelopmental disorders, providing theoretical reference for early prevention, intervention and treatment in children.

Key words: vitamin D, vitamin D receptor, gene polymorphisms, neurodevelopmental disorders

摘要: 维生素D及其受体在人体不同区域有广泛表达,后者介导活性维生素D的所有分子功能,其基因多态性已被证实与多种发育障碍类疾病易感性相关。现对维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进行综述,以期为患儿临床早期预防、干预和治疗提供理论参考。

关键词: 维生素D, 维生素D受体, 基因多态性, 神经发育障碍

CLC Number: