Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (6): 661-667.DOI: 10.11852/zgetbjzz2022-1258

• Meta Analysis • Previous Articles     Next Articles

Systematic review of the prevalence and risk factors of tic disorders in Chinese children

JIANG Yanlin, ZHANG Qiang, ZHAI Rui, PENG Yaqi, TAI Ran, WANG Junhong   

  1. Department of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Received:2022-11-08 Revised:2023-02-02 Online:2023-06-10 Published:2023-06-02
  • Contact: WANG Junhong,


姜妍琳, 张蔷, 翟睿, 彭雅琪, 太然, 王俊宏   

  1. 北京中医药大学东直门医院儿科,北京 100700
  • 通讯作者: 王俊宏,E-mail:
  • 作者简介:姜妍琳(1998-),女,山东人,硕士研究生在读,主要研究方向为儿科神经精神类疾病。
  • 基金资助:

Abstract: Objective To systematically retrieved the relevant data and analyze the prevalence and risk factors of tic disorders (TD) in China,in order to provide data reference for further study of TD. Methods A literature search of the CNKI, VIP, SinoMed, WanFang Data, PubMed, Embase and Web of Science databases for relevant observational studies, published from database inception to October 2022, was performed. Literature screening, data extraction and evaluation of risk of bias were independently conducted by two researchers. Data analysis was performed using R software. Results Forty-five studies, including 271 172 children and 10 594 TD children, were included in the Meta-analysis. The overall pooled prevalence of TD in China was 2.68% (95%CI:1.47% - 4.83%). Meta-regression analysis revealed that diagnostic criteria were the main source of study heterogeneity. The pooled prevalence of the TD subgroup, defined according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-Ⅳ), was 1.22% (95%CI:0.79% - 1.86%) and its prevalence in males and females was 1.67% (95%CI:0.91% - 3.04%) and 1.21% (95%CI:0.83% - 1.78%), respectively. Factors associated with TD included preterm birth, abnormal birth weight, neonatal jaundice, other perinatal factors, poor dietary habits, excessive use of electronic devices, history of high fever or febrile convulsions, recurrent respiratory infection, rhinopathy or asthma, attention-deficit hyperactivity disorder or other neurological comorbidities, sleep disorder, family history, psychiatric abnormality during pregnancy, corporal punishment, spoil, single-parent families, emotional lability, and high stress levels. Conclusions The prevalence of TD in China is similar to that in other countries, and males are more prevalent than females. The occurrence of TD is closely related to perinatal factors, chronic respiratory disease, and family stability.

Key words: tic disorders, prevalence rate, risk factor, Meta-analysis

摘要: 目的 系统评价中国儿童抽动障碍(TD)患病率及致病危险因素,为早期研究提供相关数据。方法 检索CNKI、VIP、CBM、WanFang Data、PubMed、Embase和Web of Science数据库中从建库至2022年10月期间所有相关的观察性研究资料,由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R语言进行Meta分析。结果 共纳入45篇文献,总计271 172名儿童,TD患儿10 594人,我国儿童TD的总患病率为2.68%(95%CI:1.47%~4.83%),Meta回归显示诊断标准为主要异质性来源,以DSM-Ⅳ为诊断标准的TD的总患病率为1.22%(95%CI:0.79%~1.86%),男童总患病率为1.67%(95%CI:0.91%~3.04%),女童总患病率为1.21%(95%CI:0.83%~1.78%)。TD致病的危险因素包括早产、异常出生体重、新生儿黄疸病史、围生期其他不利因素、不良饮食习惯、长时间看电子产品、高热或高热惊厥史、反复呼吸道感染、鼻病或哮喘、注意力缺陷多动障碍及其他神经系统共患病、睡眠障碍、抽动障碍家族史、家族精神性疾病史、母亲孕期精神或情绪异常、家教严厉或打骂体罚的教育方式、家教溺爱、单亲家庭或留守儿童或家庭不和睦、任性发脾气/性格敏感、压力大。结论 我国抽动障碍患病率与全球数据接近,男童较女童患病率高,发病与围生期不利因素、慢性呼吸系统疾病、家庭环境等密切相关。

关键词: 抽动障碍, 患病率, 危险因素, Meta分析

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