|  National Scientific Council on the Developing Child.Early experiences can alter gene expression and affect long-term development:Working paper No.10[R].National Scientific Council on the Developing Child,2010:12.
 Okano M,Bell DW,Haber D,et al.DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development[J].Cell,1999,99(3):247-257.
 Takizawa T,Nakashima K,Namihira M,et al.DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain[J].Dev Cell,2002,1(6):749-758.
 Ding Q,Vaynman S,Akhavan MM,et al.Insulin-like gro wth factor I interfaces with brain-derived neurotropic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function[J].Neuroscience,2006,140(3):823-833.
 Gomez-Pinilla F,Zhuang Y,Feng J,et al.Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation[J].Eur J Neurosci,2011,33(3):383-390.
 Sølvsten CA,de Paoli F,Christensen JH,et al.Voluntary ph ysical exercise induces expression and epigenetic remodeling of VegfA in the rat hippocampus[J].Mol Neurobiol,2016,55(1):567-582.
 Barrès R,Yan J,Egan B,et al.Acute exercise remodels promoter methylation in human skeletal muscle[J].Cell Metab,2012,15(3):405-411.
 Benevento M,van de Molengraft M,van Westen R,et al.The role of chromatin repressive marks in cognition and disease:A focus on the repressive complex GLP/G9a[J].Neurobiol Learn Mem,2015,124:88-96.
 Zhong T,Ren F,Huang CS,et al.Swimming exercise ameliorates neurocognitive impairment induced by neonatal exposure to isoflurane and enhances hippocampal histone acetylation in mice[J].Neuroscience,2016,316:378-388.
 de Meireles LC,Bertoldi K,Cechinel LR,et al.Treadmill exercise induces selective changes in hippocampal histone acetylation during the aging process in rats[J].Neurosci Lett,2016,634:19-24.
 Cechinel LR,Basso CG,Bertoldi K,et al.Treadmill exercise induces age and protocol-dependent epigenetic changes in prefrontal cortex of Wistar rats[J].Behav Brain Res,2016,313:82-87.
 Spindler C,Cechinel LR,Basso C,et al.Treadmill exercise alters histone acetyltransferases and histone deacetylases activities in frontal cortices from wistar rats[J].Cell Mol Neurobiol.2014,34(8):1097-1101.
 Zhang D,Tang Z,Huang H,et al.Metabolic regulation of gene expression by histone lactylation[J].Nature,2019,574(7779):575-580.
 Bartel DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281.
 Saab BJ,Mansuy IM.Neuroepigenetics of memory formation and impairment:The role of microRNAs[J].Neuropharmacology,2014,80:61-69.
 Mcneill E,van Vactor D.MicroRNAs shape the neuronal landscape[J].Neuron,2012,75(3):363-379.
 Lin Q,Wei W,Coelho CM,et al.The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory[J].Nat Neurosci,2011,14(9):1115-1117.
 Wayman GA,Davare M,Ando H,et al.An activity-regulated microrna controls dendritic plasticity by down-regulating P250gap[J].Proc Natl Acad Sci U S A,2008,105(26):9093-9098.
 Bao TH,Miao W,Han JH,et al.Spontaneous running wheel improves cognitive functions of mouse associated with miRNA expressional alteration in hippocampus following traumatic brain injury[J].J Mol Neurosci,2014,54(4):622-629.
 Valadi H,Ekström KK,Bossios A,et al.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J].Nat Cell Biol,2007,9(6):654-659.
 Cortz MA,Bueso-Ramos C,Ferdin J,et al.MicroRNAs in body fluids--the mix of hormones and biomarkers[J].Nat Rev Clin Oncol,2011,8(8):467-477.
 Flowers E,Won GY,Fukuoka Y.MicroRNAs associated with exercise and diet:a systematic review[J].Physiol Genomics,2015,47(1):1-11.
 Radom-Aizik S,Zaldivar F,Szu-Yun Leu,et al.Effects of exercise on microRNA expression in young males peripheral blood mononuclear cells[J].Clin Transl Sci,2012,5(1):32-38.
 Joviic＇ A,Roshan R,Moisoi N,et al.Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of Neuronal Phenotypes[J].J Neurosci.,2013,33(12):5127-5137.
 Harraz MM,Eacker SM,Wang X,et al.MicroRNA-223 is neuroprotective by targeting glutamate receptors[J].Proceedings of the National Academy of Sciences,2012,109(46):18962-18967.
 Denham J,O′Brien BJ,Harvey JT,et al.Genome-wide sperm DNA methylation changes after 3 months of exercise training in humans[J].Epigenomics,2015:1-15.
 Short AK,Yeshurun S,Powell R,et al.Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety[J].Transl Psychiatry.2017,7(5):e1114.
 Mcpherson NO,Owens JA,Fullston T,et al.Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring[J].Am J Physiol Endocrinol Metab,2015,308(9):E805-E821.
 Weissgerber TL,Wolfe LA,Davies GAL,et al.Exercise in the prevention and treatment of maternal-fetal disease:a review of the literature[J].Appl Physiol Nutr Metab,2006,31(6):661-74
 Clapp JF.Morphometric and neurodevelopmental outcome at age five years of the offspring of women who continued to exercise regularly throughout pregnancy[J].J Pediatr,1996,129(6):856-863.
 Esteban-Cornejo I,Martinez-Gomez D,Tejero-González,et al.Maternal physical activity before and during the prenatal period and the offspring′s academic performance in youth.The UP&DOWN study[J].J Matern Fetal Neonatal Med,2016,29(9):1414-1420.
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