品行障碍青少年静息态脑功能局部一致性研究

中国儿童保健杂志 ›› 2011, Vol. 19 ›› Issue (3): 210-213.

品行障碍青少年静息态脑功能局部一致性研究

王朋朋¹,张劲松^1,2,夏卫萍²,廖祥鹏¹

1 上海交通大学医学院附属新华医院儿童与青少年保健科,上海市环境与儿童健康重点实验室,上海 200092;
2 上海交通大学医学院附属新华医院临床心理科,上海 200092

收稿日期:2010-11-11 发布日期:2011-03-06 出版日期:2011-03-06
通讯作者: 张劲松,E-mail:zhangjsk@yahoo.com
作者简介:王朋朋(1982-),女,山东人,硕士研究生在读,研究方向为儿童心理行为问题的机制及干预
基金资助:
国家“十一五”科技支撑计划的子课题(2007BAI17B03);上海市科学技术委员会科研计划项目(10411966300)

Regional homogeneity in the patients with conduct disorder: a resting-state functional magnetic resonance imaging study

WANG Peng-peng¹, ZHANG Jin-song^1,2, XIA Wei-ping², LIAO Xiang-peng¹

1 Department of Child and Adolescent Health Care, Xinhua Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children's Environmental Health, Shanghai 200092, China;
2 Department of Medical Psychology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China

Received:2010-11-11 Online:2011-03-06 Published:2011-03-06

摘要/Abstract

摘要： 【目的】探讨品行障碍(conduct disorder, CD)青少年在静息态下脑功能磁共振的特点。【方法】对12名符合DSM-IV品行障碍诊断标准的12～18岁青少年和11名正常对照进行静息态的功能磁共振扫描,采用局部一致性(ReHo)作为测量指标进行数据分析,比较CD组和正常组间脑功能的差异。【结果】经过比较校正发现,与正常组相比,CD组在两侧额叶、左侧楔前叶和顶下小叶的ReHo值降低,在左侧颞叶、梭状回和右侧前扣带回ReHo值升高。【结论】与正常组相比,品行障碍青少年在静息状态下的脑功能存在异常,这些脑区可能在品行障碍的发病机制中起着重要的作用。

关键词: 品行障碍, 磁共振成像, 局部一致性

Abstract: 【Objective】 To investigate the differences of brain spontaneous activity in resting state between adolescents with conduct disorder(CD) and matched controls using function magnetic imaging(fMRI). 【Method】 11 cases diagnosed with DSM-IV and 11 normal controls underwent resting-state fMRI, the data were analyzed using a newly reported method called Regional Homogeneity(ReHo) to analyze fMRI data between CD and normal controls. 【Result】 Compared with normal controls, CD showed decreased ReHo in bilateral frontal lobe and left inferior parietal and precuneus and increased in left temporal lobe and left fusiform gyrus and right anterior cingulated. 【Conclusion】 The results suggest that CD showed abnormal activity in resting state compared with the normal controls.

Key words: conduct disorder, magnetic resonance imaging, regional homogeneity

中图分类号:

R749.94

王朋朋,张劲松,夏卫萍,廖祥鹏. 品行障碍青少年静息态脑功能局部一致性研究[J]. 中国儿童保健杂志, 2011, 19(3): 210-213.

WANG Peng-peng, ZHANG Jin-song, XIA Wei-ping, LIAO Xiang-peng. Regional homogeneity in the patients with conduct disorder: a resting-state functional magnetic resonance imaging study[J]. journal1, 2011, 19(3): 210-213.

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