中国儿童保健杂志 ›› 2011, Vol. 19 ›› Issue (4): 376-378.

• 经验交流 • 上一篇    下一篇

特发性身材矮小儿童全血微量元素及血清骨碱性磷酸酶的变化

张健,李俊新,张璐   

  1. 青岛市妇女儿童医疗保健中心检验科,山东 青岛 266011
  • 收稿日期:2010-11-22 发布日期:2011-04-06 出版日期:2011-04-06
  • 通讯作者: 李俊新,E-mail:li-jun-xin20@sohu.com
  • 作者简介:张健(1970-),男,山东人,主管检验师,本科学历,主要从事生化检验工作

Changes of blood trace elements and serum BALP in children with idiopathic short stature

ZHANG Jian, LI Jun-xin, ZHANG Lu   

  1. Department of Laboratory Medicine, Maternal and Children Hospital of Qingdao, Qingdao, Shandong 266011, China
  • Received:2010-11-22 Online:2011-04-06 Published:2011-04-06

摘要: 【目的】 探讨特发性身材矮小( idiopathic short stature, ISS) 儿童全血铜、铁、钙、镁、锌、铅以及血清骨碱性磷酸酶(bone alkaline phosphatase, BALP)水平,了解其对身高的影响。 【方法】 测定ISS组儿童及正常对照组儿童全血铜、铁、钙、镁、锌、铅及血清BALP水平并比较分析。 【结果】 ISS组儿童血铅及血清BALP水平均高于相应年龄段健康对照组儿童,血钙、血锌均低于对照组儿童,差异有统计学意义(P<0.05或<0.01)。 【结论】 铅暴露对儿童的身高有不良影响,可能是引起儿童ISS的因素之一,而血钙和血锌缺乏也影响了儿童的身高,此外ISS儿童体内BALP水平升高,可用于其疗效监测。

关键词: 特发性身材矮小, 血铅, 微量元素, 骨碱性磷酸酶

Abstract: 【Objective】 To measure the levels of blood trace elements and serum bone alkaline phosphatase(BALP) in children with idiopathic short stature and investigate their influences on the children's height. 【Method】 The levels of Blood Ca, Zn, Fe Cu, Mg, Pb and serum BALP were measured and analyzed in both idiopathic short stature group and control group. 【Result】 Both blood Ca, Zn levels were significantly lower than those of control group, but blood Pb and serum BALP levels were apparently higher than those of control group. 【Conclusions】 Pb exposure can influence children's height and that may be one factor of ISS as well as the short of blood Ca and Zn. In addition, the level of serum BALP in children with idiopathic short stature can be used as a curative effect symbol.

Key words: idiopathic short stature, serum Pb, trace element, bone alkaline phosphatase

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