关键词: 脐血, 甲状腺过氧化物酶抗体, 新生儿, Gesell评估

Abstract: Objective To investigate the clinical significance of thyroid peroxidase antibody (TPOAb) detection in umbilical cord blood. Methods The thyroid function of umbilical cord blood was saved and tested, the relationship between TPOAb of umbilical cord blood and the thyroid function of mother and neonate, and its effects on neonatal short-term growth was analysed. Results 1)The positive neonatal cord blood TPOAb were related to maternal abnormal thyroid function, abnormal serum TSH and abnormal TPOAb of mother (χ²=48.55, 13.716, 251.1, respectively, P<0.001).2)The umbilical cord blood FT4 level of the neonates with positive umbilical cord blood TPOAb was lower than those with negative TPOAb neonates (P<0.05).3) Positive umbilical cord blood TPOAb had effects on neonatal birth weight(OR=3.239, 95%CI:1.072~9.781, P<0.05), birth length (OR=9.483, 95%CI:3.228~27.35, P<0.05) and head circumference(OR=3.669, 95%CI:2.34~5.75, P<0.05).4)The neonates with positive cord blood TPOAb had effects on their weight (OR=3.827, 95%CI:1.396~10.492, P<0.05) and personal-social ability(OR=2.8, 95%CI:1.178~6.654, P<0.05) when they were 5 months old. Conclusions Positive umbilical cord blood TPOAb is related to maternal abnormal thyroid function during pregnancy and can affect the physique and intelligence development of the neonates, therefore, strengthening the screening of thyroid function and thyroid autoantibody of gestational mother and closely follow-up those positive umbilical cord blood TPOAb neonates should be advocated.

Key words: umbilical cord blood, thyroid peroxidase antibody, neonate, Gesell assessment