孕期维生素D水平与新生儿不良健康结果关系的研究进展

doi:10.11852/zgetbjzz2018-26-03-13

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (3): 276-278.DOI: 10.11852/zgetbjzz2018-26-03-13

孕期维生素D水平与新生儿不良健康结果关系的研究进展

陈晓利综述,仰曙芬审校

哈尔滨医科大学附属第二医院儿内科,黑龙江哈尔滨 150086

收稿日期:2017-07-22 发布日期:2018-03-10 出版日期:2018-03-10
通讯作者: 仰曙芬,E-mail:yangshufen56@sina.com
作者简介:陈晓利(1990-),女,河南人,在读硕士研究生,主要研究方向为儿童保健。
基金资助:
黑龙江省小儿佝偻病早期诊断和治疗技术课题

Research progress on the relationship between the level of vitamin D during pregnancy and the adverse health consequences of the newborns

CHEN Xiao-li, YANG Shu-fen

Department of Pediatrics,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150086,China

Received:2017-07-22 Online:2018-03-10 Published:2018-03-10
Contact: YANG Shu-fen,E-mail:yangshufen56@sina.com

摘要/Abstract

摘要： 维生素D(Vit D)是一种类固醇衍生物,对人体具有重要作用,Vit D缺乏可导致多种疾病。近年来发现孕期Vit D缺乏现象严重。本文主要从孕期Vit D缺乏对新生儿不良出生结局的影响进行综述,以期提高对孕期Vit D补充的认识,减少新生儿不良出生结局的发生。

关键词: 孕妇, 新生儿, 维生素D缺乏

Abstract: Vitamin D (Vit D) is a kind of steroid derivatives that play important an important role in humanbeings.Vitamin D deficiency can lead to a variety of diseases.In recent years,vitamin D deficiency is found to be serious during pregnancy.The impacts of vitamin D deficiency during pregnancy on the neonatal adverse outcomes are reviewed in this article in order to improve the understanding of vitamin D supplements during pregnancy and to reduce the incidence of neonatal adverse outcomes.

Key words: pregnant woman, neonate, vitamin D deficiency

中图分类号:

R179

陈晓利综述,仰曙芬审校. 孕期维生素D水平与新生儿不良健康结果关系的研究进展[J]. 中国儿童保健杂志, 2018, 26(3): 276-278.

CHEN Xiao-li, YANG Shu-fen. Research progress on the relationship between the level of vitamin D during pregnancy and the adverse health consequences of the newborns[J]. journal1, 2018, 26(3): 276-278.

参考文献

[1] Maghbooli Z,Hossein-Nezhad A,Shafaei AR,et al.Vitamin D status in mothers and their newborns in Iran[J].BMC Pregnancy Childbirth,2007,7:1.
[2] Vinkhuyzen AA,Eyles DW,Burne TH,et al.Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods:The Generation R Study[J].J Steroid Biochem Mol Biol,2016,164:161-167.
[3] 胡海婷.孕期维生素D水平与子代出生结局的关联研究[D].合肥:安徽医科大学,2016.
[4] 王晨.孕母及新生儿维生素D水平的临床研究[D].北京:北京协和医院,2016.
[5] Wagner CL,Baggerly C,McDonnell SL,et al.Post-hoc comparison of vitamin D status at three timepoints during pregnancy demonstrates lower risk of preterm birth with higher vitamin D closer to delivery[J].J Steroid Biochem Mol Biol,2015,148:256-260.
[6] Qin LL,Lu FG,Yang SH,et al.Does maternal vitamin D deficiency increase the risk of preterm birth:A meta-analysis of observational studies[J].Nutrients,2016,8(5):301.
[7] Liu NQ,Hewison M.Vitamin D.The placenta and pregnancy[J].Arch Biochem Biophys,2012,523(1):37-47.
[8] Liu NQ,Kaplan AT,Lagishetty V,et al.Vitamin D and the regulation of placental inflammation[J].J Immunol,2011,186(10):5968-5974.
[9] Liu N,Kaplan AT,Low J,et al.Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway[J].Biol Reprod,2009,80(3):398-406.
[10] Dunlop AL,Taylor RN,Tangpricha V,et al.Maternal vitamin D,folate,and polyunsaturated fatty acid status and bacterial vaginosis during pregnancy[J].Infect Dis Obstet Gynecol,2011,2011:216-217.
[11] Grant WB.Adequate vitamin D during pregnancy reduces the risk of premature birth by reducing placental colonization by bacterial vaginosis species[J].MBio,2011,2(2):e00022-11.
[12] Liu PT,Stenger S,Li H,et al.Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response[J].Science,2006,311(5768):1770-1773.
[13] Dror DK,Allen LH.Vitamin D inadequacy in pregnancy:biology,outcomes,and interventions[J].Nutr Rev,2010,68(8):465-477.
[14] Chun SK,Shin S,Kim MY,et al.Effects of maternal genetic polymorphisms in vitamin D-binding protein and serum 25-hydroxyvitamin D concentration on infant birth weight[J].Nutrition,2017,35:36-42.
[15] Khalessi N,Kalani M,Araghi M,et al.The relationship between maternal vitamin D deficiency and low birth weight neonates[J].J Family Reprod Health,2015,9(3):113-117.
[16] Hansdottir S,Monick MM.Vitamin D effects on lung immunity and respiratory diseases[J].Vitam Horm,2011,86:217-237.
[17] Bergman P,Lindh AU,Björkhem-Bergman L,et al.Vitamin D and respiratory tract infections:A systematic review and meta-analysis of randomized controlled trials[J].PLoS One,2013,8(6):e65835.
[18] Dinlen N,Zenciroglu A,Beken S,et al.Association of vitamin D deficiency with acute lower respiratory tract infections in newborns[J].J Matern Fetal Neonatal Med,2016,29(6):928-932.
[19] Mookherjee N,Rehaume LM,Hancock RE.Cathelicidins and functional analogues as antisepsis molecules[J].Expert Opin Ther Targets,2007,11(8):993-1004.
[20] Cizmeci MN,Kanburoglu MK,Akelma AZ,et al.Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis:a case-control study from a tertiary care center in Turkey[J].Eur J Pediatr,2015,174(6):809-815.
[21] Bruce D,Yu S,Ooi JH,et al.Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling[J].Int Immunol,2011,23(8):519-528.
[22] Zhang H,Shih DQ,Zhang X.Mechanisms underlying effects of 1,25-Dihydroxyvitamin D₃ on the Th17 cells[J].Eur J Microbiol Immunol (Bp),2013,3(4):237-240.
[23] Jenkins DD,Lee T,Chiuzan C,et al.Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy[J].Pediatr Crit Care Med,2013,14(8):786-795.
[24] Mutlu M,Sarlaydln M,Aslan Y,et al.Status of vitamin D,antioxidant enzymes,and antioxidant substances in neonates with neonatal hypoxic-ischemic encephalopathy[J].J Matern Fetal Neonatal Med,2016,29(14):2259-2263.
[25] Hollis BW,Johnson D,Hulsey TC,et al.Vitamin D supplementation during pregnancy:double-blind,randomized clinical trial of safety and effectiveness[J].J Bone Miner Res,2011,26(10):2341-2357.

孕期维生素D水平与新生儿不良健康结果关系的研究进展

Research progress on the relationship between the level of vitamin D during pregnancy and the adverse health consequences of the newborns

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	韦菊芳, 陈吉健. 2015—2021年南宁市西乡塘区新生儿低出生体重变化趋势及影响因素分析[J]. 中国儿童保健杂志, 2023, 31(7): 785-789.
[2]	张雪怡, 张亚昱, 李佳. 微塑料对新生儿健康影响的研究[J]. 中国儿童保健杂志, 2023, 31(4): 399-403.
[3]	张娟娟, 马金旗, 曾军安, 何阿玲. 新生儿遗传性出血性毛细血管扩张症1例并文献回顾[J]. 中国儿童保健杂志, 2023, 31(2): 225-228.
[4]	张笃飞, 张湘云. 海南省2020年新生儿先天性心脏病的流行病学调查[J]. 中国儿童保健杂志, 2023, 31(1): 91-95.
[5]	王惠萍, 王莉, 高琼, 白铂亮, 马颖君. 极低出生体重坏死性小肠结肠炎患儿体格及神经发育的研究[J]. 中国儿童保健杂志, 2023, 31(1): 96-100.
[6]	袁源, 陈密. 脐带血miR-431表达水平与新生儿先天性听力障碍关系的研究[J]. 中国儿童保健杂志, 2023, 31(1): 101-104.
[7]	刘俐, 魏思萌, 姜忒. 新生儿营养与儿童早期发展[J]. 中国儿童保健杂志, 2022, 30(8): 879-883.
[8]	杨茹莱. 原发性免疫缺陷病和脊髓性肌萎缩症临床特点及新生儿早期联合筛查实践[J]. 中国儿童保健杂志, 2022, 30(7): 697-701.
[9]	刘建宏, 黄方. 血清NFP、Nrf2水平与新生儿窒息早期脑损伤的关系[J]. 中国儿童保健杂志, 2022, 30(7): 787-791.
[10]	董丽萍, 张振, 崔艳国, 李庆波. 淄博市甲基丙二酸血症筛查指标应用分析[J]. 中国儿童保健杂志, 2022, 30(7): 792-795.
[11]	刘晔, 步军, 王亮君. 新生儿C型尼曼匹克病2例报告[J]. 中国儿童保健杂志, 2022, 30(6): 694-696.
[12]	彭真, 屠文娟. 定量脑电图在新生儿脑功能研究中的应用[J]. 中国儿童保健杂志, 2022, 30(4): 405-408.
[13]	倪松平, 华孝真, 张素春. 2型糖尿病和妊娠期糖尿病对新生儿呼吸窘迫综合征的影响[J]. 中国儿童保健杂志, 2022, 30(4): 450-453.
[14]	房军臣, 冯丽娟, 陈新, 张玉东, 蒲伟丛, 马莉. 父源单亲二倍体型Beckwith-Wiedemann综合征2例及文献复习[J]. 中国儿童保健杂志, 2022, 30(4): 461-464.
[15]	中国优生优育协会婴幼儿发育专业委员会. 高危新生儿行为神经发育早期干预专家共识[J]. 中国儿童保健杂志, 2022, 30(3): 233-236.