关键词: 促性腺激素释放激素类似物, 特发性中枢性性早熟, 女童, 成年身高

Abstract: Objective To evaluate the effect of gonadotropin-releasing hormone analogues(GnRHa) on improving final adult height(FAH) in girls with idiopathic central precocious puberty(ICPP),and to analyze the related factors. Methods Data of 26 ICPP girls,who had been treated with GnRHa alone and had reached or approached their FAH in the affiliated hospital of Nanjing Unversity of traditonal Chinese medicine from May, 2009 to July,2011,were retrospectively analyzed. Results The 26 girls with ICPP were treated by GnRHa for(22.50±5.48)months,followed up for(58.0±7.44)months,and finally the mean FAH was(161.50±4.41)cm,significantly higher than the prediction of adult height before treatment [(157.23±5.51)cm,P<0.01].The net height gain was(4.27±4.05)cm.The body mass index(BMI) before treatment,at the end of treatment and after reaching FAH was(16.32±1.67)kg/m²,(17.39±2.41)kg/m² and(19.95±2.21)kg/m² respectively,and all remained in the nomal range of age(±1s).The average menstrual age of 26 ICPP girls was(12.5±0.7)years old.The FAH was positively correlated with height when the medication stopped and menarche age(P<0.01 or <0.05),and negatively related to bone age when medication stopped(P<0.01). Conclusion GnRHa can significantly improve the final height in girls with ICPP,and the FAH is correlated with the height,bone age when the medication stopped,and menarche age.Moreover,youth development of children after medication stopped is similar to that of the normal children.

Key words: gonadotropin-releasing hormone analogues, idiopathic central precocious puberty, girls, final adult height