关键词: 血锌缺乏, 微量元素, 咳嗽变异性哮喘, 预后

Abstract: Objective To discuss the effects of zinc deficiency on pulmonary function,airway inflammation and clinical efficacy in children with cough variant asthma(CVA),so as to provide evidence for clinical assessment and treatment of CVA. Methods A total of 60 CVA children with zinc deficiency admitted to Yulin First Hospital from February 2016 to February 2018 were selected as participants(zinc deficiency group),meanwhile 60 CVA children with similar age and normal zinc level were selected for control study(normal zinc group) during the same period. Both group received conventional treatment of 8 weeks course. Lung function,induced sputum EOS,IL-4 and IL-10 levels were recorded before and after treatment. Clinical efficacy and recurrence of one year follow-up after treatment were recorded. Results FVC,FEV1%,PEF and MMEF after treatment significantly increased in both groups(P<0.05). EOS,IL-4 and IL-10 levels in induced sputum after treatment were significantly improved in both groups(P<0.05),and the improvement of the above indicators after treatment in deficient zinc group was worse than normal zinc group(P<0.05). Clinical efficacy grade of zinc deficiency group was significantly lower than normal zinc group(Z=2.197,P=0.028). Recurrence rate of zinc deficiency group was higher than that of normal zinc group(χ²=3.962,P=0.046). Multiple Logistic regression analysis showed that serum zinc deficiency was risk factor of poor control. Conclusions Serum zinc deficiency is not conducive to improvement of lung function and airway inflammation,and is closely related to recurrence. It may be risk factor for poor control of the disease. Therefore trace elements should be regularly monitored,and zinc supplementation should be given timely and appropriately so as to improve prognosis.

Key words: zinc deficiency, trace elements, cough variability asthma, prognosis