关键词: 血尿酸升高, 生活方式干预, 学龄前儿童

Abstract: Objective To investigate the effectiveness of life style intervention on preschool children with hyperuricemia(HUA). Methods A cross-sectional survey was carried out in six central urban districts of Tianjin from March to June 2015. And 242 children aged from 3 to 6 years with the elevated blood uric acid levels were randomly divided into the intensive intervention group(n=122) and routine health care group(n=120). Children with the elevated blood uric acid levels in the intensive intervention group were intensively intervened on the diet,exercise guide,health education. Children in both groups were reexamined after at least 3 months,and finally 204 children had reexamination. Results The levels of blood uric acid in the intensive intervention group and in routine health care group were (357.7±44.3)μmol/L and (363.3±44.5)μmol/L at baseline time. The levels of blood uric acid in the intensive intervention group and in routine health care group were (287.6±42.1)μmol/L and (336.2±65.2)μmol/L at reexamination time. The reduction of levels of blood uric acid in the intensive intervention group was more than that in routine health care group and the difference was of statistical significance(t=-4.841,P<0.001). At the time of reexamination,the rates of recovery to the normal level in the intensive intervention group and routine health care group were 72.7% and 44.7%,respectively(χ²=16.586,P<0.001). Conclusion The individualized intervention of life styles and health education may reduce the prevalence of hyperuricemia in preschool children

Key words: elevated blood uric acid level, life style intervention, preschool children