关键词: 生长激素缺乏症, 体重指数, 疗效分析

Abstract: Objective To explore the clinical effect of recombinant human growth hormone(rhGH) on treatment of children with prepubertal growth hormone deficiency(GHD) based on different body mass index(BMI),in order to provide basis for individualized treatment. Methods Totally 76 children with GHD accepting more than one year treatment of rhGH in Guangdong Women and Children′s Hospital from January 2016 to December 2018 were involved in this study.According to the BMI threshold of obesity and overweight published by China Obesity Task Group in 2004, children with GHD were divided into three groups:normal BMI group(30 cases), overweight group(23 cases) and obesity group(23 cases).Before and after treatment, height, BMI, bone age, insulin-like growth factor(IGF-1) and insulin-like growth factor-binding protein 3(IGFBP-3) levels were tested. Height velocity(HV), height standard deviation scores(HtSDS), fasting blood glucose, insulin, thyroid stimulating hormone(TSH), FT3, FT4 were measured. Results After one year of treatment, the HV and HtSDS of the three groups were significantly improved(P<0.05), and the therapeutic effect of the normal BMI group was better than that of the overweight and obesity group(P<0.05).There was no significant difference on treatment efficacy between the overweight and obesity group(P>0.05).The BMI of overweight and obesity group significantly decreased after treatment(P<0.05).Compared with those before treatment, fasting glucose, insulin, TSH, FT3 and FT4 levels did not show significant differences after treatment(P>0.05). Conclusionss RhGH can significantly improve the growth rate of GHD children in prepuberty.After correcting other factors, when rhGH is used to treat overweight and obese children with GHD, it is speculated that a larger dose of rhGH may be needed to obtain a better growth rate.

Key words: growth hormone deficiency, body mass index, curative effect analysis