关键词: 降钙素原变化率, 新生儿, 肺部感染, C反应蛋白, 维生素A, 预测价值

Abstract: Objective To analyze the predictive value of the change rate of procalcitonin for pulmonary infection in neonates,so as to provide basis for early identification of critical newborns. Methods A total of 400 newborns complicated with pulmonary infection in Shenzhen Baoan District Maternal and Child Health Hospital were enrolled in this study from July 2018 to August 2019.The levels of procalcitonin at admission and 24 hours later were measured and compared.The change rate of procalcitonin in children was calculated[(procalcitonin at admission at 24 h-procalcitonin at admission) / procalcitonin at admission].According to the change rate of procalcitonin,all children were divided into control group(change rate of procalcitonin≤0.00%) and observation group(change rate of procalcitonin>0.00%),with 200 cases in each group.The levels of C-reactive protein (CRP) and vitamin A in the two groups of neonates were tested,and then the predictive value of C-reactive protein,vitamin A and procalcitonin rate in neonates with pulmonary infection were compared. Results Compared with the control group,the C-reactive protein content in the neonates was significantly lower(t=-30.601),while the vitamin A content was significantly higher(t=-15.460) in the observation group.Furthermore,the length of stay was significantly longer(t=13.783) and the incidence of sepsis was significantly higher(χ²=4.712,P<0.05) in the observation group.In addition,the area under the curve of procalcitonin change rate in diagnosing of pulmonary infection complicated with sepsis in newborns was 0.821 (95%CI:0.803-0.878,P<0.05),which was higher than that of C-reactive protein and vitamin A. Conclusion The change rate of procalcitonin has a significant predictive value for neonatal pulmonary infection.

Key words: change rate of procalcitonin, neonate, pulmonary infection, C-reactive protein, vitamin A, predictive value