关键词: 早期环境, 褪黑素, 情绪, 大鼠

Abstract: 【Objective】 To explore the influence of early environment on emotional behavior of rats and the involved melatonin pathway. 【Methods】 The different environments-the enriched environment(EE) ,the isolated environment(IE) for rats were established.The the head-touch test was performed to assess anxious and nervous ability of the rats after postnatal 29 days(P29).The levels of serum melatonin of rats were tested by the emission immunology method after early environment intervention. 【Results】 1) In the handle-touch test,the scores of nervous and the pain in EE group were(1.13±0.35,1.87±0.83)> the normal control group(1.67±0.72,2.60±0.91)> the isolated environment group(2.13±0.64,3.47±0.64)(P<0.05).2) The level of serum melatonin of rats in EE group was(49.67±6.67)ng/mL,which was more than that in control group(45.81±4.09) ng/mL.The level of serum melatonin in IE group was (40.53±3.23)ng/mL,which was the lowest among three groups(P<0.001).3) There was negative correlation between melatonin levels in rats with stressors,pain stimulation. 【Conclusion】 The melatonin may play an important role in emotion development,which regulated by the early environment.

Key words: early environment, melatonin, developmental behavior, rats