5-羟色胺与对立违抗障碍相关研究进展

doi:10.11852/zgetbjzz2015-23-12-16

中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (12): 1284-1286.DOI: 10.11852/zgetbjzz2015-23-12-16

5-羟色胺与对立违抗障碍相关研究进展

李雪怡(综述), 肖农(审校)

重庆医科大学附属儿童医院,重庆 400014

收稿日期:2014-12-13 发布日期:2015-12-10 出版日期:2015-12-10
通讯作者: 肖农,E-mailxiaonongwl@163.com
作者简介:李雪怡(1991-),女,湖南人,住院医师,硕士研究生,主要研究方向为儿童康复。

Received:2014-12-13 Online:2015-12-10 Published:2015-12-10

摘要/Abstract

摘要： 本文主要介绍对立违抗障碍(oppositional defiant disorder,ODD)、5-羟色胺(5-hydroxy tryptamin,5-HT)的相关概念以及论述它们之间的关系。ODD的发病机理目前尚未明确,涉及生物学、社会心理学等。5-HT系统异常在ODD发病过程中有着重要的作用。文章就5-HT的角度来阐述其与ODD的关系,主要从5-HT相关基因、5-HT受体、5-HT信号传导等予以综述。

关键词: 对立违抗障碍, 5-羟色胺, 色氨酸羟化酶, 5-羟色氨酸转运体, 单胺氧化酶, 5-羟色胺受体

中图分类号:

R179

李雪怡(综述), 肖农(审校). 5-羟色胺与对立违抗障碍相关研究进展[J]. 中国儿童保健杂志, 2015, 23(12): 1284-1286.

0
/ / 推荐

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/10.11852/zgetbjzz2015-23-12-16

https://manu41.magtech.com.cn/Jwk_zgetbjzz/CN/Y2015/V23/I12/1284

参考文献

[1] 苏林雁,王长虹.青少年对立违抗性障碍[J].中国实用儿科杂志,2007,22(03):161-163.
[2] American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders.5th.DSM-V[M].Washington,American Psychiatric Association,2013.
[3] 黄广文,苏林雁,马敏,等.对立违抗性障碍儿童行为特征及伙伴关系初步研究[J].中国儿童保健杂志,2006,14(4):341-343.
[4] 杨莉,王玉凤.儿童注意缺陷多动障碍共病研究[J].中华医学杂志,2003,83(13):1190-1191.
[5] 刘春梅,罗学荣,叶海森,等.伴对立违抗障碍的注意缺陷多动障碍儿童行为特征[J].中国行为医学科学,2008,17(12):1089-1090.
[6] Catherine T,Mo Z,Adrian R,et al.A common genetic factor explains the covariation among ADHD ODD and CD symptoms in 9-10 year old boys and girls[J].Journalof abnormal child psychology,2009,37(2):153-167.
[7] 孙凌,苏林雁,刘永忠.长沙市中小学生对立违抗性障碍的现况及对照研究[J].中华精神科杂志,2001,34(4):208-211.
[8] Nordquist N,Oreland L.Serotonin,genetic variability,behaveiour,and psychiatric disorders-a review[J].Upsala Journal of medical sciences,2010,115(1):2-10.
[9] 段云峰,吴晓丽,王涛,等.5-羟色胺和多巴胺与攻击行为的关联研究进展[J].生命科学,2013,10(25):1027-1035.
[10] Castellanos FX,Elia JA,Kruesi MJP,et al.Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder[J].Psychiatry Research,1994,52(3):305-316.
[11] 苏林雁,谢光荣,高雪屏,等.注意缺陷多动障碍合并对立违抗性障碍患儿血清5-羟色胺的对照研究[J].中华精神科杂志,2001,34(4):230-232.
[12] Yoon H,Kim Y.Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients[J].Progress in Neuro Psychopharmacology And Biological psychiatry,2008,32(5):1293-1297.
[13] Veenstra-VanderWeele J,Cook Jr EH.Knockout mouse point to second form of tryptophan hydroxylase[J].MolecularInterventions,2003,3(2):72-75.
[14] Tusing ME,Ford L.Examining preschool cognituve abilities using a CHC framework[J].International Journal of Testing,2004,4(2):91-114.
[15] Jonas W,Naozumi A,Lise G,et al.Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation:A perspective[J].Psychoneuroendocrinolog,2011,36(3):393-405.
[16] Ingeborg W,Jeffrey AM,Per MK,et al.Characterization of wild-type and mutant forms of human tryptophan hydroxylase2[J].Journal of Neurochemistry,2007,100(6):1648-1657.
[17] Tobias B,Katja B,Susann S,et al.Molecular genetics of attention deficit/hyperactivity disorder:an overview[J].European Child Adolescent Psychiatry,2010,19(3):237-257.
[18] Campos SB,Miranda DM,Souza BR,et al.Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder of suicidal behavior[J].Journal of Psychiatric Research,2010,44(5):271-274.
[19] Holmes A,Murphy DL,Crawley JN.Reduced aggression in mice lacking the serotonin transporter[J].Psychopharmacology,2002,161(2):160-167.
[20] Caspi A,Mcclay JL,Moffitt TE,et al.Role of genotype in the cycle of violence in maltreated children[J].Science,2002,297(5582):851-854.
[21] Beevers CG,Wells T,Ellis AJ,et al.Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli[J].Journal of Abnormal Psychology,2009,118(3):670-681.
[22] Brammer WA,Lee SS.Prosociality and negative emotionality mediate the association of serotonin transporter genotype with childhood ADHD and ODD[J].Journal of Clinical child & Adolescent Psychology,2013,42(6):809-819.
[23] Buckholtz JW,Meyerlindenberg A.MAOA and the neurogenetic architecture of human aggression[J].Trends in Neuroscience,2008,31(3):120-129.
[24] Andreas Me,Joshua B,Bhaskar K,et al.Neural mechanisms of genetic risk for impulsivity and violence in humans[J].Proceedings of the National Academy of Science,2006,103(16):6269-6274.
[25] Guan L,Wanq B,Chen Y,et al.A high-density single-nucleotide polymorphism screen of 23 candidate genes in attention deficit hyperactivity disorder:Suggesting multiple susceptibility genes among Chinese Han population[J].Molecular Psychiatry,2008,14(5):546-554.
[26] Snoek H,Van GSHM,Matthys W,et al.Serotonergic functioning in children with oppositional defiant disorder:A sumatriptan challenge study[J].Biological Psychiatry,2002,51(4):319-325.
[27] Muller C,Carey RM,Huston JP,et al.Serotonin and psychostimulant addiction:focus on 5-HT1A-receptors[J].Prog Neurobiol,2007,81(3):133-178.
[28] Nelson RJ,Chiavegatto S.Molecular basis of aggression [J].Trends in Neurosciences,2001,24(12):713-719.
[29] Ghadirivasfi M,Nohesara S,Ahmadkhaniha H,et al.Hypomethylation of the serotonin receptor type-2A Gene(HTR2A) ant T102C polymorphic site in DNA derived form the saliva of patients with schizophrenia and bipolar disorder[J].American Journal of Medical Genetics,Part B,Neuropsychiatricgenetics,2011,156(5):536-545.

5-羟色胺与对立违抗障碍相关研究进展

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 5

编辑推荐

Metrics

[1]	王椿淇, 刘磊, 刘洋, 许志勇, 王一诺, 庄绪秀, 闻德亮. 血清单胺氧化酶与儿童青少年肥胖之间的关系研究[J]. 中国儿童保健杂志, 2021, 29(2): 151-155.
[2]	夏颖, 匡桂芳, 王蕾, 马文蓓, 谭歆. 儿童智力和反应抑制功能分析[J]. 中国儿童保健杂志, 2018, 26(10): 1052-1055.
[3]	江文庆, 李焱, 杜亚松, 李彩霞, 李梦瑶. 注意缺陷多动障碍与对立违抗障碍男童的情绪调节过程缺陷[J]. 中国儿童保健杂志, 2017, 25(5): 440-443.
[4]	车立纯,刘秀梅,陈琅,刘世国,衣明纪. 抽动障碍大鼠模型的行为学特征及机制研究[J]. 中国儿童保健杂志, 2016, 24(12): 1274-1277.
[5]	黄丽,匡桂芳,邢雨晗,张楠,沈贵荣. 注意缺陷多动障碍共患对立违抗障碍患儿行为与父母间冲突的相关性研究[J]. 中国儿童保健杂志, 2015, 23(3): 234-237.