中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (1): 42-46.DOI: 10.11852/zgetbjzz2020-1750

所属专题: 孤独症谱系障碍

• 综述 • 上一篇    下一篇

孤独症谱系障碍合并躯体感觉障碍的神经生物学机制研究

胡梅新, 李慧萍, 徐秀   

  1. 复旦大学附属儿科医院,上海 201102
  • 收稿日期:2020-10-07 修回日期:2020-10-27 发布日期:2021-01-10 出版日期:2021-01-10
  • 通讯作者: 徐秀,E-mail:xuxiu@shmu.edu.cn
  • 作者简介:胡梅新(1996-),女,广西人,在读研究生,主要研究方向为儿童孤独症谱系障碍疾病。
  • 基金资助:
    科技部慢病重大专项(2016YFC1306205);国家自然科学基金青年项目(81601327)

Review in neurobiological mechanisms of somatosensory disorders in autism spectrum disorder

HU Mei-xin, LI Hui-ping, XU Xiu   

  1. Children's Hospital of Fudan University,Shanghai 201102,China
  • Received:2020-10-07 Revised:2020-10-27 Online:2021-01-10 Published:2021-01-10
  • Contact: XU Xiu,E-mail:xuxiu@shmu.edu.cn

摘要: 躯体感觉障碍是指躯体感觉系统对来自皮肤和深层组织的刺激感知和处理过程出现异常,是孤独症谱系障碍(ASD )的核心症状之一,严重影响患儿社交、沟通、适应等技能发展和预后。查阅文献,关于躯体感觉障碍的研究非常多,但ASD与躯体感觉障碍之间的产生机制仍不完全清楚。由此,本文将综述躯体感觉障碍的神经生物学机制,进一步分析已知的ASD合并躯体感觉障碍的神经生物学机制。为理解躯体感觉障碍在ASD发病中的作用,以及探索ASD干预方法提供思路。

关键词: 孤独症谱系障碍, 躯体感觉障碍, 神经生物学

Abstract: Somatosensory disorder refers to abnormalities in the somatosensory system's perception and processing of stimuli from the skin and deep tissues.It is one of the core symptoms of autism spectrum disorder (ASD),which seriously affects children's social,communication and adaptation skills development and prognosis.There are many studies on somatosensory disorders,but the mechanism between ASD and somatosensory disorders is still unclear.Therefore,this article will review the neurobiological mechanisms of somatosensory disorders and further analyze the known neurobiological mechanisms of ASD combined with somatosensory disorders,thereby providing an idea for understanding the role of somatosensory disorders in the pathogenesis of ASD and for exploring ASD intervention methods.

Key words: autism spectrum disorder, somatosensory disorder, neurobiology

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