关键词: 振幅整合脑电图, 神经元特异性烯醇化酶, S100-β蛋白, 脑损伤, 早产儿

Abstract: Objective To analyze the diagnostic value of amplitude-integrated electroencephalogram (aEEG) combined with serum neuron-specific enolase (NSE) and S100-β protein levels in the diagnosis of cerebral injury in premature infants, so as to provide clinical basis for the early diagnosis. Methods A total of 98 premature infants with high-risk factors for cerebral injury in neonatal wards of Xinxiang Central Hospital from May 2016 to May 2018 were selected as participants in this study.According to the diagnostic criteria in Expert Consensus for Diagnosis and Prevention of Brain Injury in Premature Infants, the premature infants were divided into cerebral injury group (n=56) and non-cerebral injury group (n=42).And aEEG was performed in all neonates, and serum levels of NSE and S100-β protein were tested.The sensitivity, specificity, and accuracy of single indicator detection and combined detection of aEEG, serum NSE and S100-β in the diagnosis of premature infants with cerebral injury were analyzed and compared.Then the receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC value) was recorded. Results The sensitivity values of single indicator detection and combined detection of aEEG, serum NSE and S100-β in the diagnosis of premature infants with cerebral injury were 82.14%, 71.43%, 69.64%, and 94.64%, respectively; The specificity values were 66.67%, 80.95%, 76.19%, and 61.90%, respectively; The accuracy rates were 75.51%, 75.51%, 72.45%, and 80.61%, respectively, and the AUC values were 0.744, 0.762, 0.729 and 0.783, respectively.It was indicated that the combined detection could significantly improve the sensitivity (P<0.05). Conclusion aEEG, serum NSE and S100-β can be used as diagnostic indicators for premature infants with cerebral injury, and combined detection of the three indexes can significantly improve the diagnostic efficacy.

Key words: amplitude-integrated electroencephalogram, neuron-specific enolase, S100-β protein, cerebral injury, premature infants