关键词: 癫痫, 注意缺陷多动障碍, 共患病, 哌甲酯

Abstract: Objective To investigate the clinical significance of methylphenidate treatment in epilepsy comorbid attention deficit hyperactivity disorder (ADHD) children in the disorder in children medication. Methods From our hospital specialist outpatients pediatric neurologist,58 cases of children epilepsy comorbid ADHD were collected and divided groups according to the type of epilepsy and whether taking methylphenidate .After 3 months of treatment .Electroencephalogram (EEG) abnormality rate change value,changes in seizure frequency and improvement of ADHD symptoms among the groups.Results After three months' treatment,between the groups of the same type of seizures were compared,EEG abnormality rate and the reduced value of seizure frequency were no statistical differences(P>0.05).Comparison of SNAP-IV scale scores in not taking methylphenidate groups before and after treatment was no statistical difference (P>0.05),while taking methylphenidate groups' SNAP-IV score was significantly decreased after treatment (P<0.05). Conclusion The study do not find the phenomenon that methylphenidate could aggravate epilepsy condition.Giving methylphenidate to epilepsy comorbid ADHD children is effective to improve the symptoms of hyperactivity impulsivity.

Key words: epilepsy, attention deficit hyperactivity disorders, comorbidity, methylphenidate