关键词: 外源性雌激素, 苯甲酸雌二醇, 青春期前, 大鼠, 生殖系统

Abstract: Objective To observe the influence of extrinsic estrogen on the reproductive system of prepubertal male rats. Methods A total of 45 rats were randomly divided into high dose group,low dose group and control group.E2B was administered through gastric tube in male rats with 15 000 μg/kg,15 μg/kg,0 μg/kg,dose respectively.One time every two days,after three weeks,normal breeding to ninth weeks,then put to death and draw materials,and measured corresponding index. Results Compared with control group,T concentration of low dose decreased(P<0.05),but FSH,LH and E2 concentration increased,the differences were statistically significant (P<0.01).Four kinds of hormone of high dose changed more apparent(P<0.01).In two experimental group,the differences of T,FSH,LH and E2 concentration had statistical significances (P<0.05).The testicular reproductive small tube and AGD of two experimental group were both abnormal changed,but changes in high dose group were more obvious than those in low group.Conclusion EES can change the normal serum sex hormone levels and reproductive small tube of preadolescence male rats.

Key words: extrinsic estrogen, estradiol benzoate, preadolescence, rats, reproductive system