关键词: :宫内发育迟缓, 追赶生长, 胰岛素抵抗, 大鼠

Abstract: Objective To investigate the relationship between catch-up growth at early stage and insulin sensitivity of intrauterine growth retardation (IUGR) rat. Method An intrauterine growth retardation (IUGR) animal model was established by protein malnutrition during the mother's late pregnancy.Appropriate growth was defined by a weight within one SD of the colony mean,named as IUGR catch up growth group(IUGR CG),weight which exceed the above standerd named as IUGR over catch up group (IUGR OCG).Weight growth rate was calculated by standerd deviation score (SDS).At 21d,2 months and 4 months after birth,offspring rats were fasted for 12 h and then angular vein blood was collected to measure fasting plasma glucose (FPG) and fasting serum insulin level,then insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI) were calculated.IUGR hyperglycemia group (IUGR HG) was defined by 95% limit controls of FPG. Results 1)The mean offspring birth weight of IUGR group was (4.37±0.69)g,which was lower than that of control group (7.03±0.55)g(t=-20.75,P<0.05).In IUGR group,the incidence of IUGR offspring was 93.33%.2)HOMA-IR was significantIy higher in IUGR rats than that in the control group at the age of 2 months to 4 months (P<0.05).ISI was significantly lower at 2 months of age and continued to 4m (P<0.05).3) FPG of IUGR OG was significantly higher than that of IUGR CG and control group at 2 months (P<0.05).4) The growth rate of IUGR rat at 7d was the fastest,which was statistically highly correlated with insulin resistance index of 2 month and 4 month (P<0.05). Conclusion The more faster catch up growth at early age,the IUGR rats are more prone to have insulin resistance at adulthood.

Key words: intrauterine growth retardation, catch up growth, insulin resistance, rat