关键词: 糖尿病, 妊娠, 新生儿, 体脂含量, 性别差异

Abstract: Objective To explore the difference in association between maternal gestational diabetes mellitus(GDM) and neonatal fat mass by sex,and to provide theoretical support for early nutrition interventions. Methods Population-based study of all neonates born to women with or without GDM (n=231) in Wuxi Maternal and Child Health Care Hospital from January to July 2015.Neonatal anthropometric measures (weight,height,skinfold thickness) were collected within 24 to 48 hours of birth by trained health staff.Self-administered questionnaires were used to collect maternal health status during pregnancy. Results 1)Compared with control group,fat mass percentage and fat mass were significant higher in the neonates of GDM mothers (P<0.01),but not birth weight and length (P>0.05).2)After the adjustment for maternal pre-pregnancy BMI,gestational weight gain,delivery mode,maternal age,educational level and other confounding factors,maternal gestational diabetes mellitus was the main predictor of fat mass in male newborns,but not in female offspring.There were 80 g fat mass difference in the case group than control group in male babies. Conclusions This study demonstrated that the increment of a newborn's fat mass related to maternal gestational diabetes mellitus appears greater for male neonates.The nutritional status of infants with maternal abnormal glucose tolerance observed in pregnancy should be closely monitored,especially for the boys' follow-up and nutritional guidance.

Key words: diabetes, gestational, newborn, fat mass, sex difference