关键词: 呼吸道感染, 维生素A, 维生素D, 维生素E, 儿童

Abstract: Objective To investigate the association of serum levels of vitamin A, D and E with recurrent respiratory tract infections(RRTIs). Methods Children aged 6 months-15 years in People′s Hospital of Guangxi Zhuang Autonomous Region were enrolled to finish a face-to-face survey from January to December 2017. Totally 171 children with RRTIs were selected as the RRTI group, whereas 156 health children were used as control group. Blood samples were collected, and high performance liquid chromatography (HPLC) was used to measure serum levels of vitamin A and E. The serum level of 25(OH)D₃ was tested by chemiluminescence. The differences on serum levels of vitamin A, D, E were analyzed between RRTI group and control group. Results The average levels of vitamin A[(0.30±0.06) mg/L vs.(0.39±0.07) mg/L], vitamin D₃ [(72.41±25.59) nmol/L vs.(84.84±29.96) nmol/L] and vitamin E [(8.90±2.32) mg/L vs. (9.72±2.61)mg/L] in RRTI group were significantly lower than those in control group(P＜0.01).The deficiency and insufficiency rate of vitamin A、D₃, and vitamin E insufficiency rate in RRTI group were significantly higher than those in normal control group (P<0.05). Logistic regression analysis showed that vitamin A level lower than 0.3 mg/L (OR=19.225,95%CI: 9.136-40.453) and vitamin D₃ level lower than 50 nmol/L(OR=2.891,95%CI:1.186-7.044) increased the risk of RRTIs in children. Conclusion The insufficiency of vitamin A and D₃ may be critically associated with RRTIs of children.

Key words: respiratory infection, vitamin A, vitamin D, vitamin E, children