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中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (8): 886-890.

• 基础研究 • 上一篇    下一篇

神经性毒剂梭曼中毒致犬心电图的变化及宾赛克嗪的救治作用

张津津1,2, 龙超良2, 唐渊2, 王汝欢4, 宋丽雪2,5, 汪海2,3, 夏云峰1   

  1. 1解放军总医院第一附属医院干一科, 北京100037;
    2军事医学科学院毒物药物研究所,北京100850;
    3军事医学科学院卫生学环境医学研究所, 天津300050;
    4北京恩华医药研究院, 北京100039;
    5北京军区总医院药剂科, 北京100700
  • 收稿日期:2008-03-15 修回日期:2008-06-10 出版日期:2008-08-26 发布日期:2020-10-12
  • 通讯作者: 汪海, 男, 博士, 研究员, 博士生导师, 研究方向:分子药理学和心脑血管新药。Tel:010-66932651 E-mail:wh9588@yahoo.com
  • 作者简介:张津津, 女, 硕士生, 主治医师, 研究方向:心血管。Tel:13911660882 E-mail:zjj304301@yahoo.com.cn

Changes of electrocardiogram induced by neurotoxin soman and rescue of benthiactzine in dogs

ZHANG Jin-jin1,2, LONG Chao-liang2, TANG Yuan2, WANG Ru-huan4, SONG Li-xue2,5, WANG Hai2,3, XIA Yun-feng1   

  1. 1Ward for Cadre, First Affiliated Hospital of PLAGeneral Hospital, Beijing 100037, China;
    2Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;
    3Institute of Environmental Medicine and Hygiology, Academy of Military Medical Sciences, Beijing 100850, China;
    4Beijing Enhua Academy of Medicine, Beijing 100039, China;
    5Beijing aeneral Hospital of PLA Military Region, Beijing 100700, China
  • Received:2008-03-15 Revised:2008-06-10 Online:2008-08-26 Published:2020-10-12

摘要: 目的:观察神经性毒剂梭曼中毒导致犬心电图和心肌酶的变化及新型抗毒剂宾赛克嗪(benthiactzine)的解救作用。方法:健康成年雄性杂种犬7只, 体重12~15 kg 。在麻醉状态下, 每次肌肉注射1/3LD 梭曼(1LD=10 μg/kg), 每10 min 追加1次的累积染毒;以平均动脉压降至40~45 mm Hg(1mm Hg=0.133kPa)为循环衰竭标准。观察在梭曼染毒前后及宾赛克嗪救治后犬的血压、心率、心电图和心肌酶的变化。结果:染毒后诱发犬进行性循环衰竭, 心率减慢, 房室传导阻滞, 部分P 波消失, 出现室性逸搏, 结性心律;T波高耸, 波峰尖锐。血液中肌酸磷酸激酸同工酶(CK-MB)和乳酸脱氢酶(LDH)水平显著增加(P<0.05), 表明梭曼染毒导致犬循环衰竭发生心脏受损明显。宾赛克嗪0.1mg/kg 静脉注射, 57.1%的犬在3~5 min 恢复窦性心律, 心率增加, 房室传导阻滞消失, 心电图T 波可基本恢复, 但血液中CK-MB 和LDH 在救治后无显著恢复。结论:胆碱酯酶抑制剂类毒物梭曼中毒可引起严重心律失常, 宾赛克嗪可给予有效的救治。

关键词: 梭曼, 宾赛克嗪, 循环衰竭, 心电图,

Abstract: AIM:To investigate the changes of electrocardiogram(ECG), LDH and CK-MB caused by soman, and the therapeutic effects of benthiactzine. METHODS:7 healthy male dogs, weighing 12-15 kg, were given intramuscularly 1/3LD soman (1LD= 10 μg/kg)per ten minutes.The mean blood pressure lower than 40-45 mm Hg was defined as circulatory failure.The changes of ECG, heart rate, blood pressure, LDH and CK-MB were recorded either before and after soma was given or after benthiactzine was given. RESULTS:It was observed that decreased heart rate, A-V block, high and sharp T wave with or without P wave in ECG of dogs after soma was given.Meanwhile, the levels of CK-MB and LDH were increased significantly (P<0.05).The treatment of benthiactzine made the ECG recovery normal, but CK-MB and LDH did not obviously change.CONCLUSION:The cholinesterase inhibitor soman leads to serious arrhythmia which can be remedied by benthiactzine.

Key words: soman, benthiactzine, circulatory failure, ECG, dog

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