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中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (7): 744-746.

• 基础研究 • 上一篇    下一篇

刺五加对急性胰腺炎模型大鼠体内炎性介质的影响

朱健平1, 李媚芳2, 陈博3, 邓修健2   

  1. 1广东医学院药理教研室, 2广东医学院第一临床学院, 3广东医学院生理科学实验室, 东莞 523808, 广东
  • 收稿日期:2008-05-15 修回日期:2008-07-19 出版日期:2008-07-26 发布日期:2020-10-14
  • 作者简介:朱健平,男,学士,副教授,研究方向:药理学。Tel:0769-22896169 E-mail:gdmczjp@gdmc.edu.cn

Effects of acanthopanacis senticosi on inflammatory mediators in rats with acute pancreatitis

ZHU Jian-ping1, LI Mei-fang2, CHEN Bo3, DENG Xiu-jian2   

  1. 1Department of Pharmacology, 2First Clinical College, 3Laboratory of Physiology Science, Guangdong Medical College, Dongguan 523808, Guangdong, China
  • Received:2008-05-15 Revised:2008-07-19 Online:2008-07-26 Published:2020-10-14

摘要: 目的:观察刺五加对急性胰腺炎模型大鼠体内炎性介质的影响。方法:经胆胰管逆行注射5%牛磺胆酸钠制备急性胰腺炎模型,术后定时取血,测定血清中肿瘤坏死因子(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)以及淀粉酶(AMY)、脂肪酶(LIP)、磷脂酶A2(PLA2)等的变化。结果:刺五加能降低血清中TNF-α、IL-1、IL-6的水平,降低血清中AMY、LIP、PLA2的活性。结论:刺五加对血清中TNF-α等多种细胞因子和AMY、PLA2的影响,可能是其治疗急性胰腺炎的作用基础。

关键词: 刺五加, 急性胰腺炎, 磷脂酶A2, 细胞因子

Abstract: AIM: To investigate the effect of acanthopanacis senticosi on the inflammatory mediators in acute pancreatitis(AP) rat models.METHODS: The rat models of AP were induced by intraductal administration of 5% sodium taurocholate, which were killed on time after model induction.The levels of TNF-α, IL-1, IL-6, amylase, lipase and phospholipase A2 in the blood samples were determined.RESULTS: In the acanthopanax senticosus group, the levels of TNF-α, IL-1 and IL-6 were decreased significantly, the activation of serum amylase, lipase, phospholipase A2 were attenuated significantly.CONCLUSION: Acanthopanacis senticosi has protective effect on AP model through cytokine pathways, within which the inhibitory effects on TNF-α, IL-1, IL-6 and phospholipase A2 were the most important mechanism.

Key words: acanthopanacis senticosi, acute pancreatitis, phospholipase A2, cytokine

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