欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (9): 1004-1008.

• 基础研究 • 上一篇    下一篇

碘化N-正丁基氟哌啶醇对大鼠心脏缺血和再灌注室性心律失常的拮抗作用

高分飞, 石刚刚, 李海青, 黄展勤, 张艳美, 周燕琼   

  1. 汕头大学医学院药理学教研室, 汕头515041, 广东
  • 收稿日期:2007-03-05 修回日期:2007-08-10 出版日期:2007-09-26 发布日期:2020-10-30
  • 通讯作者: 石刚刚, 男, 博士, 教授, 博士生导师, 研究方向:心血管药物的开发与研究。Tel:0764-8900301 E-mail:ggshi@stu.edu.cn
  • 作者简介:高分飞, 男, 医学硕士, 在读博士生, 助理研究员, 主要从事心血管药物的研究。Tel:0764-8900432 E-mail:ffgao@stu.edu.cn
  • 基金资助:
    国家自然科学基金项目(30672465);广东省自然科学基金重点项目(06118928)和面上项目(07008206);汕头市重点科技计划项目(2006)

Effects of N-n-butyl haloperidol iodide on ischemia and reperfusion-induced ventricular arrhythmias in rat heart

GAO Fen-fei, SHI Gang-gang, LI Hai-qing, HUANG Zhan-qin, ZHANG Yan-mei, ZHOU Yan-qiong   

  1. Department of Pharmacology, Shantou University Medical College, Shantou 515041, Guangdong, China
  • Received:2007-03-05 Revised:2007-08-10 Online:2007-09-26 Published:2020-10-30

摘要: 目的:研究碘化N-正丁基氟哌啶醇(F2) 对心肌缺血和再灌注引发的室性心律失常的拮抗作用。方法:采用大鼠Langendorff 灌流心脏模型, 通过结扎左冠脉前降支缺血20 min, 解除结扎再灌注, 引出室性心律失常。缺血前5 min 用含不同浓度F2 的台氏液灌流, 观察其对缺血和再灌注期室性心律失常发生率的影响, 同时观察F2 对心电图上PR、QT、RR间期的影响。用心房起搏(5 Hz) 防止心率变慢, 观察1 μmol/L F2 对缺血和再灌注室性心律失常、PR间期的影响。结果:F2 可浓度依赖地降低缺血和再灌注期室性心律失常发生率, 并减慢心率, 延长PR间期。在心房起搏控制心律下, 仍具有拮抗缺血和再灌注室性心律失常、延长PR 间期的作用。结论:F2 对大鼠心脏缺血和再灌注性心律失常具有直接的抑制作用。

关键词: 碘化N-正丁基氟哌啶醇, 心律失常, 缺血再灌注

Abstract: AIM: To study the antiarrhythmic effects of N-n-butyl haloperidol iodide (F2) on ischemia- and reperfusion-induced ventricular arrhythmias.METHODS: Using the Langendorff-perfused rat heart model, the ventricular arrhythmias were induced by ligating the left anterior descending coronary artery for 20 minutes before the release of the ligature.Each concentration of F2 was administered 5 min prior to the induction of regional ischemia.The effects of F2 on arrhythmias during periods of ischemia and reperfusion and the effects on PR, QT, RR intervals were investigated.When rat hearts were paced (5 Hz) via the right atrium to prevent bradycardia, the antiarrhythmic effects and the effect on PR interval of 1 μmol/L F2 were observed.RESULTS: F2 reduced ischemia- and reperfusion-induced ventricular arrhythmias in concentration-dependent manner, and widened PR, RR intervals.The same effects were observed even in paced rat hearts.CONCLUSION: F2 could reduce ischemia- and reperfusion-induced ventricular arrhythmias directly in the isolated rat hearts.

Key words: N-n-butyl haloperidol iodide, arrhythmia, ischemia-reperfusion

中图分类号: