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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (5): 548-550.

• 研究原著 • 上一篇    下一篇

联苯双酯对肾移植受者环孢素A 全血浓度的影响及肝毒性的防护作用

余爱荣, 吴笑春, 李罄, 辛华雯, 朱敏   

  1. 广州军区武汉总医院临床药理科, 武汉430070, 湖北
  • 收稿日期:2003-12-20 修回日期:2004-02-25 发布日期:2020-11-22
  • 通讯作者: 余爱荣,女, 硕士研究生, 主管药师, 主要从事临床药理学研究。Tel:027-87665785  E-mai l:yarfwy@163.com
  • 作者简介:吴笑春, 女, 主任药师, 主要从事临床药学研究。Tel:027-87665785 E-mai l:wxcpss @163.com
  • 基金资助:
    湖北省自然科学基金项目(No2002AB114)

Effects of bifendate on the blood concentration and hepatic toxicity of cyclosporine A in renal transplanted recipients

YU Ai-Rong, WU Xiao-Chun, LI Qing, XIN Hua-Wen, ZHU Min   

  1. Department of clinical pharmacology, Wuhan General Hospital, Guangzhou Military Command, Wuhan 430070, Hubei, China
  • Received:2003-12-20 Revised:2004-02-25 Published:2020-11-22

摘要: 目的 研究肾移植受者应用联苯双酯(bifendate,BFD) 对环孢素A(cyclosporin A, CsA) 全血浓度的影响及肝毒性的防护作用。 方法 28 例患者(合用组) 合用CsA 与BFD, 30 例患者(对照组) 单服CsA, 以CsA 全血浓度及肝功能作为临床评价指标。 结果 BFD 能有效降低肾移植受者异常升高的ALT和AST, 合用BFD 后CsA 全血浓度与合用前比较降幅达17.7 %, 与对照组比较亦有显著性降低(P <0.01), 停用BFD 后CsA 全血浓度明显升高, 增幅达36.3 %。 结论 BFD 能防护肾移植受者CsA 肝毒性并能明显降低CsA 血浓度。

关键词: 联苯双酯, 肾移植受者, 环孢素A, 肝毒性, 全血浓度

Abstract: AIM: To study the effects of bifendate on the blood concentration and hepatic toxicity of cyclosporine A in renal transplanted recipients. METHODS: 28 cases with renal transplantation in coadministration group were treated with CsA and BFD, and 30 cases with renal transplantation in control group received only CsA.Blood levels of CsA, biochemistry indexes for liver and renal function were determined. RESULTS: Blood concentrations of CsA in patients combined with BFD went down by 17.7 % compared with those before taking BFD and had a significant decrease compared with control group.Blood concentrations of CsA were significantly increased after stopping BFD administration.Mean blood concentrations were increased by 36.3 %.BFD could effectively reduce higher ALT and AST. CONCLUSION: BFD can markedly decrease the blood concentration of CsA in renal transplanted recipients.

Key words: bifendate, renal transplanted recipients, cyclosporin A, hepatic toxicity, drug concentration in blood

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