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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (9): 992-996.

• 研究原著 • 上一篇    下一篇

SARS 患者应用甲基强的松龙注射剂治疗情况与不良反应分析

王睿, 周筱青, 陈马昆, 周践, 魏荣1, 董军, 曹秀堂, 周亚春1, 王瑾, 郭代红, 王洁松1, 朱秀美1, 梁蓓蓓, 徐艳萍, 周先志1   

  1. 解放军总医院药材处, 北京100853;
    1解放军小汤山医院, 北京100000
  • 收稿日期:2004-06-29 修回日期:2004-08-04 出版日期:2004-09-26 发布日期:2020-11-23
  • 通讯作者: 王睿, 女, 研究员, 教授, 博士生导师, 研究方向:临床药理学。Tel:010-66939409 Email:wangrui301 @vip. sina. com
  • 基金资助:
    国家863 高技术研究发展计划资助项目(№2003AA208107)

Effects and adverse drug reactions of mtrisone in the treatment of patients with severe acute respiratory syndrome

WANG Rui, ZHOU Xiao-Qing, DONG Jun, WEI Rong1, CAO Xiu-Tang, ZHOU Ya-Chun1, WANG Jin, GUO Dai-Hong, CHEN Kun, ZHOU Jian, WANG Jie-Song1, ZHU Xiu-Mei1, LIANG Bei-Bei, XU Yan-Ping, ZHOU Xian-Zhi1   

  1. Department of Pharmacy, General Hospital of Chinese PLA, Beijing 100853, China;
    1Xiaotangshan Hospital of PLA, Beijing 100000, China
  • Received:2004-06-29 Revised:2004-08-04 Online:2004-09-26 Published:2020-11-23

摘要: 目的: 了解应用甲基强的松龙注射剂SARS患者的病情、治疗情况和不良反应。方法: 回顾性分析小汤山医院临床确诊的680 例SARS 患者的病案、用药记录及药品不良反应发生情况, 将其分为应用和未用甲基强的松龙注射剂2 组, 描述性分析两组病例基本病情和不良反应。结果: 使用甲基强的松龙注射剂患者的病情程度较未使用甲基强的松龙注射剂的患者严重, 平均服用药品种类也较多;使用甲基强的松龙注射剂患者的药品不良反应(ADR) 发生率要高于未使用甲基强的松龙注射剂患者, 发现该组病人出现高血糖、低血钾和白细胞升高等药物不良反应。结论: 在SARS 治疗过程中需慎重使用甲基强的松龙注射剂, 严密观察其药物不良反应。

关键词: 严重急性呼吸综合症, 药品不良反应, 甲基强的松龙注射剂, 高血糖, 低血钾

Abstract: AIM: To study effects and adverse drug reactions of mtrisone in the treatment of patients with severe acute respiratory syndrome.METHODS: The information of the medications in 680 patients with severe acute respiratory syndrome (SARS) in Xiaotangshan Hospital was collected by HIS system and the effects and ADRs of metrisone were staiated.RESULTS: The kinds of drugs of SARS patients who had been cured by metrisone were more than those which were not cured by metrisone. Condition of SARS patients who had been cured by metrisone was more serious than those which were not cured by metrisone. The ADRs rate, blood glucose and leukocyte of SARS patients who had been cured by metrisone are higher than those which were not cured by metrisone while blood K+ is lower.CONCLUSION: The utilization of metrison to SRAS patient should be more cautious to balance the effects and ADRs of metrisone.

Key words: severe acute respiratory syndrome(SARS), ADRs, metrisone, hyperglycemia, hypokalemic

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